Activation of NRF2 by dexamethasone in ataxia telangiectasia cells involves KEAP1 inhibition but not the inhibition of p38

Oxidative stress has been shown to play a crucial role in the pathophysiology of the neurodegenerative disease Ataxia Telangiectasia. We have recently demonstrated that Dexamethasone treatment is able to counteract the oxidative state by promoting nuclear factor erythroid 2-related factor 2 (NRF2) n...

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Detalles Bibliográficos
Autores principales: Biagiotti, Sara, Bianchi, Marzia, Rossi, Luigia, Chessa, Luciana, Magnani, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527213/
https://www.ncbi.nlm.nih.gov/pubmed/31107893
http://dx.doi.org/10.1371/journal.pone.0216668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527213/
https://www.ncbi.nlm.nih.gov/pubmed/31107893
http://dx.doi.org/10.1371/journal.pone.0216668

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