Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis

Tumor-infiltrating lymphocytes (TILs) are associated with prognosis in various tumors. However, it remains controversial whether the presence of TILs is related to an improved prognosis in melanoma. This meta-analysis confirmed the favorable prognostic role of the CD3+, CD4+, CD8+, FOXP3+, and CD20+...

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Autores principales: Fu, Qiaofen, Chen, Nan, Ge, Chunlei, Li, Ruilei, Li, Zhen, Zeng, Baozhen, Li, Chunyan, Wang, Ying, Xue, Yuanbo, Song, Xin, Li, Heng, Li, Gaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527267/
https://www.ncbi.nlm.nih.gov/pubmed/31143514
http://dx.doi.org/10.1080/2162402X.2019.1593806
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author Fu, Qiaofen
Chen, Nan
Ge, Chunlei
Li, Ruilei
Li, Zhen
Zeng, Baozhen
Li, Chunyan
Wang, Ying
Xue, Yuanbo
Song, Xin
Li, Heng
Li, Gaofeng
author_facet Fu, Qiaofen
Chen, Nan
Ge, Chunlei
Li, Ruilei
Li, Zhen
Zeng, Baozhen
Li, Chunyan
Wang, Ying
Xue, Yuanbo
Song, Xin
Li, Heng
Li, Gaofeng
author_sort Fu, Qiaofen
collection PubMed
description Tumor-infiltrating lymphocytes (TILs) are associated with prognosis in various tumors. However, it remains controversial whether the presence of TILs is related to an improved prognosis in melanoma. This meta-analysis confirmed the favorable prognostic role of the CD3+, CD4+, CD8+, FOXP3+, and CD20+ TILs in the overall survival of melanoma patients and found an association between the TILs present and improved overall survival. Additionally, subgroup analysis demonstrated that brisk TILs were obviously associated with OS, RFS and DSS/MSS. Thus, TILs may be a predictive biomarker in melanoma. This analysis will provide more insight into the study of TILs and predictive biomarker.
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spelling pubmed-65272672019-05-29 Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis Fu, Qiaofen Chen, Nan Ge, Chunlei Li, Ruilei Li, Zhen Zeng, Baozhen Li, Chunyan Wang, Ying Xue, Yuanbo Song, Xin Li, Heng Li, Gaofeng Oncoimmunology Review Tumor-infiltrating lymphocytes (TILs) are associated with prognosis in various tumors. However, it remains controversial whether the presence of TILs is related to an improved prognosis in melanoma. This meta-analysis confirmed the favorable prognostic role of the CD3+, CD4+, CD8+, FOXP3+, and CD20+ TILs in the overall survival of melanoma patients and found an association between the TILs present and improved overall survival. Additionally, subgroup analysis demonstrated that brisk TILs were obviously associated with OS, RFS and DSS/MSS. Thus, TILs may be a predictive biomarker in melanoma. This analysis will provide more insight into the study of TILs and predictive biomarker. Taylor & Francis 2019-04-03 /pmc/articles/PMC6527267/ /pubmed/31143514 http://dx.doi.org/10.1080/2162402X.2019.1593806 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Fu, Qiaofen
Chen, Nan
Ge, Chunlei
Li, Ruilei
Li, Zhen
Zeng, Baozhen
Li, Chunyan
Wang, Ying
Xue, Yuanbo
Song, Xin
Li, Heng
Li, Gaofeng
Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis
title Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis
title_full Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis
title_fullStr Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis
title_full_unstemmed Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis
title_short Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis
title_sort prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527267/
https://www.ncbi.nlm.nih.gov/pubmed/31143514
http://dx.doi.org/10.1080/2162402X.2019.1593806
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