Widespread intronic polyadenylation inactivates tumor suppressor genes in leukemia

DNA mutations are known cancer drivers. Here, we investigated if mRNA events that are upregulated in cancer can functionally mimic the outcome of genetic alterations. 3′-seq or RNA-seq were applied to normal and malignant B cells from chronic lymphocytic leukemia (CLL; N = 59)(1–3). We discovered wi...

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Detalles Bibliográficos
Autores principales: Lee, Shih-Han, Singh, Irtisha, Tisdale, Sarah, Abdel-Wahab, Omar, Leslie, Christina S., Mayr, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527314/
https://www.ncbi.nlm.nih.gov/pubmed/30150773
http://dx.doi.org/10.1038/s41586-018-0465-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527314/
https://www.ncbi.nlm.nih.gov/pubmed/30150773
http://dx.doi.org/10.1038/s41586-018-0465-8

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