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Widespread intronic polyadenylation inactivates tumor suppressor genes in leukemia
DNA mutations are known cancer drivers. Here, we investigated if mRNA events that are upregulated in cancer can functionally mimic the outcome of genetic alterations. 3′-seq or RNA-seq were applied to normal and malignant B cells from chronic lymphocytic leukemia (CLL; N = 59)(1–3). We discovered wi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527314/ https://www.ncbi.nlm.nih.gov/pubmed/30150773 http://dx.doi.org/10.1038/s41586-018-0465-8 |