The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells

Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function. Here, we...

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Detalles Bibliográficos
Autores principales: Villanueva, Andrea A., Puvogel, Sofía, Lois, Pablo, Muñoz-Palma, Ernesto, Ramírez Orellana, Manuel, Lubieniecki, Fabiana, Casco Claro, Fernando, Gallegos, Iván, García-Castro, Javier, Sanchez-Gomez, Pilar, Torres, Vicente A., Palma, Verónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527380/
https://www.ncbi.nlm.nih.gov/pubmed/30160193
http://dx.doi.org/10.1080/19336918.2018.1506652
Descripción
Sumario:Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function. Here, we show that NTN4 is broadly expressed in tumor, stroma and blood vessels of NB patient samples. Furthermore, NTN4 was shown to act as a cell adhesion molecule required for the migration induced by Neogenin-1 (NEO1) in SK-N-SH neuroblastoma cells. Therefore, we propose that NTN4, by forming a ternary complex with Laminin γ1 (LMγ1) and NEO1, acts as an essential extracellular matrix component, which induces the migration of SK-N-SH cells.

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