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Role of glycosylation in hypoxia-driven cell migration and invasion
Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit. In hypoxia, HIF-1α stabilizes, forms the heterodimeric complex wit...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527385/ https://www.ncbi.nlm.nih.gov/pubmed/30015560 http://dx.doi.org/10.1080/19336918.2018.1491234 |
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author | Arriagada, Cecilia Silva, Patricio Torres, Vicente A. |
author_facet | Arriagada, Cecilia Silva, Patricio Torres, Vicente A. |
author_sort | Arriagada, Cecilia |
collection | PubMed |
description | Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit. In hypoxia, HIF-1α stabilizes, forms the heterodimeric complex with HIF-1β, and binds to Hypoxia Response Elements (HRE), activating gene expression to promote metabolic adaptation, cell invasion and metastasis. Furthermore, the focal adhesion kinase, FAK, is activated in hypoxia, promoting cell migration by mechanisms that remain unclear. In this context, integrins, which are glycoproteins required for cell migration, are possibly involved in hypoxia-induced FAK activation. Evidence suggests that cancer cells have an altered glycosylation metabolism, mostly by the expression of glycosyltransferases, however the relevance of glycosylation is poorly explored in the context of hypoxia. Here, we discuss the role of hypoxia in cancer, and its effects on protein glycosylation, with emphasis on integrins and cell migration. |
format | Online Article Text |
id | pubmed-6527385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-65273852019-05-31 Role of glycosylation in hypoxia-driven cell migration and invasion Arriagada, Cecilia Silva, Patricio Torres, Vicente A. Cell Adh Migr Review Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit. In hypoxia, HIF-1α stabilizes, forms the heterodimeric complex with HIF-1β, and binds to Hypoxia Response Elements (HRE), activating gene expression to promote metabolic adaptation, cell invasion and metastasis. Furthermore, the focal adhesion kinase, FAK, is activated in hypoxia, promoting cell migration by mechanisms that remain unclear. In this context, integrins, which are glycoproteins required for cell migration, are possibly involved in hypoxia-induced FAK activation. Evidence suggests that cancer cells have an altered glycosylation metabolism, mostly by the expression of glycosyltransferases, however the relevance of glycosylation is poorly explored in the context of hypoxia. Here, we discuss the role of hypoxia in cancer, and its effects on protein glycosylation, with emphasis on integrins and cell migration. Taylor & Francis 2018-08-19 /pmc/articles/PMC6527385/ /pubmed/30015560 http://dx.doi.org/10.1080/19336918.2018.1491234 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Arriagada, Cecilia Silva, Patricio Torres, Vicente A. Role of glycosylation in hypoxia-driven cell migration and invasion |
title | Role of glycosylation in hypoxia-driven cell migration and invasion |
title_full | Role of glycosylation in hypoxia-driven cell migration and invasion |
title_fullStr | Role of glycosylation in hypoxia-driven cell migration and invasion |
title_full_unstemmed | Role of glycosylation in hypoxia-driven cell migration and invasion |
title_short | Role of glycosylation in hypoxia-driven cell migration and invasion |
title_sort | role of glycosylation in hypoxia-driven cell migration and invasion |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527385/ https://www.ncbi.nlm.nih.gov/pubmed/30015560 http://dx.doi.org/10.1080/19336918.2018.1491234 |
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