The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells

Colorectal cancer (CRC) is the third most common cancer in the United States. The exact mechanism of CRC cells metastasis is poorly understood. Actin polymerization is thought to be an initial step in the cancer cell motility cycle which drives the formation of cell protrusions and defines the direc...

Descripción completa

Detalles Bibliográficos
Autores principales: Islam, S M Anisul, Patel, Rekha, Bommareddy, Raja Reddy, Khalid, Khandker Mohammad, Acevedo-Duncan, Mildred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527392/
https://www.ncbi.nlm.nih.gov/pubmed/30417717
http://dx.doi.org/10.1080/19336918.2018.1546513
_version_ 1783420028489564160
author Islam, S M Anisul
Patel, Rekha
Bommareddy, Raja Reddy
Khalid, Khandker Mohammad
Acevedo-Duncan, Mildred
author_facet Islam, S M Anisul
Patel, Rekha
Bommareddy, Raja Reddy
Khalid, Khandker Mohammad
Acevedo-Duncan, Mildred
author_sort Islam, S M Anisul
collection PubMed
description Colorectal cancer (CRC) is the third most common cancer in the United States. The exact mechanism of CRC cells metastasis is poorly understood. Actin polymerization is thought to be an initial step in the cancer cell motility cycle which drives the formation of cell protrusions and defines the direction of migration. Cofilin, a significant actin-regulating molecule, regulates the migration of cancer cells by the formation of lamellipodia and filopodia, however, little is known about the upstream regulation of cofilin. In this study, the effect of atypical Protein Kinase C (atypical PKC) on Cofilin activity in CRC was studied. This study demonstrates that the atypical PKC inhibition impedes the metastasis of CRC cells by increasing phospho-Cofilin (S3) and changing actin organization.
format Online
Article
Text
id pubmed-6527392
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-65273922019-05-31 The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells Islam, S M Anisul Patel, Rekha Bommareddy, Raja Reddy Khalid, Khandker Mohammad Acevedo-Duncan, Mildred Cell Adh Migr Research Article Colorectal cancer (CRC) is the third most common cancer in the United States. The exact mechanism of CRC cells metastasis is poorly understood. Actin polymerization is thought to be an initial step in the cancer cell motility cycle which drives the formation of cell protrusions and defines the direction of migration. Cofilin, a significant actin-regulating molecule, regulates the migration of cancer cells by the formation of lamellipodia and filopodia, however, little is known about the upstream regulation of cofilin. In this study, the effect of atypical Protein Kinase C (atypical PKC) on Cofilin activity in CRC was studied. This study demonstrates that the atypical PKC inhibition impedes the metastasis of CRC cells by increasing phospho-Cofilin (S3) and changing actin organization. Taylor & Francis 2018-11-18 /pmc/articles/PMC6527392/ /pubmed/30417717 http://dx.doi.org/10.1080/19336918.2018.1546513 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Islam, S M Anisul
Patel, Rekha
Bommareddy, Raja Reddy
Khalid, Khandker Mohammad
Acevedo-Duncan, Mildred
The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title_full The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title_fullStr The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title_full_unstemmed The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title_short The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title_sort modulation of actin dynamics via atypical protein kinase-c activated cofilin regulates metastasis of colorectal cancer cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527392/
https://www.ncbi.nlm.nih.gov/pubmed/30417717
http://dx.doi.org/10.1080/19336918.2018.1546513
work_keys_str_mv AT islamsmanisul themodulationofactindynamicsviaatypicalproteinkinasecactivatedcofilinregulatesmetastasisofcolorectalcancercells
AT patelrekha themodulationofactindynamicsviaatypicalproteinkinasecactivatedcofilinregulatesmetastasisofcolorectalcancercells
AT bommareddyrajareddy themodulationofactindynamicsviaatypicalproteinkinasecactivatedcofilinregulatesmetastasisofcolorectalcancercells
AT khalidkhandkermohammad themodulationofactindynamicsviaatypicalproteinkinasecactivatedcofilinregulatesmetastasisofcolorectalcancercells
AT acevedoduncanmildred themodulationofactindynamicsviaatypicalproteinkinasecactivatedcofilinregulatesmetastasisofcolorectalcancercells
AT islamsmanisul modulationofactindynamicsviaatypicalproteinkinasecactivatedcofilinregulatesmetastasisofcolorectalcancercells
AT patelrekha modulationofactindynamicsviaatypicalproteinkinasecactivatedcofilinregulatesmetastasisofcolorectalcancercells
AT bommareddyrajareddy modulationofactindynamicsviaatypicalproteinkinasecactivatedcofilinregulatesmetastasisofcolorectalcancercells
AT khalidkhandkermohammad modulationofactindynamicsviaatypicalproteinkinasecactivatedcofilinregulatesmetastasisofcolorectalcancercells
AT acevedoduncanmildred modulationofactindynamicsviaatypicalproteinkinasecactivatedcofilinregulatesmetastasisofcolorectalcancercells

Ejemplares similares