Cargando…
Identifying the murine mammary cell target of metformin exposure
The heterogeneity of breast cancer makes current therapies challenging. Metformin, the anti-diabetic drug, has shown promising anti-cancer activities in epidemiological studies and breast cancer models. Yet, how metformin alters the normal adult breast tissue remains elusive. We demonstrate metformi...
Autores principales: | Shehata, Mona, Kim, Hyeyeon, Vellanki, Ravi, Waterhouse, Paul D., Mahendralingam, Mathepan, Casey, Alison E., Koritzinsky, Marianne, Khokha, Rama |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527562/ https://www.ncbi.nlm.nih.gov/pubmed/31123716 http://dx.doi.org/10.1038/s42003-019-0439-x |
Ejemplares similares
-
Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention
por: Tharmapalan, Pirashaanthy, et al.
Publicado: (2019) -
Proliferative heterogeneity of murine epithelial cells in the adult mammary gland
por: Shehata, Mona, et al.
Publicado: (2018) -
PDGFRα(+) stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
por: Joshi, Purna A., et al.
Publicado: (2019) -
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities
por: Casey, Alison E., et al.
Publicado: (2018) -
The mammary stem cell conundrum: is it unipotent or multipotent?
por: Joshi, Purna A, et al.
Publicado: (2012)