Cargando…

Mitochondrial Protein PINK1 Positively Regulates RLR Signaling

The serine/threonine kinase phosphatase and tensin homolog (PTEN)-induced putative kinase 1(PINK1) controls mitochondrial quality and plays a vital role in the pathogenesis of early-onset Parkinson's disease. However, whether PINK1 has functions in innate antiviral immunity is largely unknown....

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Jun, Yang, Rui, Zhang, Zhaoru, Liu, Qianru, Zhang, Yuanyuan, Wang, Qingqing, Yuan, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527598/ https://www.ncbi.nlm.nih.gov/pubmed/31139191 http://dx.doi.org/10.3389/fimmu.2019.01069

Ejemplares similares

BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS
por: Huang, Jing-Ping, et al.
Publicado: (2022)

ZNF205 positively regulates RLR antiviral signaling by targeting RIG-I: ZNF205 regulates RLR antiviral signaling
por: Zhong, Ni, et al.
Publicado: (2023)

Regulation of RLR-Mediated Antiviral Responses of Human Dendritic Cells by mTOR
por: Fekete, Tünde, et al.
Publicado: (2020)

Crosstalk between Autophagy and RLR Signaling
por: Ke, Po-Yuan
Publicado: (2023)

Two Duplicated Ptpn6 Homeologs Cooperatively and Negatively Regulate RLR-Mediated IFN Response in Hexaploid Gibel Carp
por: Tong, Jin-Feng, et al.
Publicado: (2021)

IRF4b and IRF8 Negatively Regulate RLR-Mediated NF-κB Signaling by Targeting MITA for Degradation in Teleost Fish
por: Yan, Xiaolong, et al.
Publicado: (2022)

Identification of DreI as an Antiviral Factor Regulated by RLR Signaling Pathway
por: Li, Shun, et al.
Publicado: (2012)

Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity
por: Huang, Shanzhi, et al.
Publicado: (2022)

Foot-and-mouth disease virus non-structural protein 2B downregulates the RLR signaling pathway via degradation of RIG-I and MDA5
por: Weerawardhana, Asela, et al.
Publicado: (2022)

Papain-like protease of SARS-CoV-2 inhibits RLR signaling in a deubiquitination-dependent and deubiquitination-independent manner
por: Ran, Xiang-Hong, et al.
Publicado: (2022)

Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop
por: Cheng, Jinbo, et al.
Publicado: (2016)

Regulatory NLRs Control the RLR-Mediated Type I Interferon and Inflammatory Responses in Human Dendritic Cells
por: Fekete, Tünde, et al.
Publicado: (2018)

Activation and Evasion of RLR Signaling by DNA Virus Infection
por: Jia, Junli, et al.
Publicado: (2021)

Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling
por: Ma, Jinzhu, et al.
Publicado: (2018)

Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling
por: Sui, Liyan, et al.
Publicado: (2023)

ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway
por: Zhang, Huirong, et al.
Publicado: (2020)

Endogenous Retroviruses (ERVs): Does RLR (RIG-I-Like Receptors)-MAVS Pathway Directly Control Senescence and Aging as a Consequence of ERV De-Repression?
por: Di Giorgio, Eros, et al.
Publicado: (2022)

E3 Ubiquitin Ligases: The Operators of the Ubiquitin Code That Regulates the RLR and cGAS-STING Pathways
por: Ji, Likai, et al.
Publicado: (2022)

TRAF7 negatively regulates the RLR signaling pathway by facilitating the K48-linked ubiquitination of TBK1
por: Huang, Jing-Ping, et al.
Publicado: (2023)

PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix
por: Thomas, Ruth E., et al.
Publicado: (2014)

Divergences of the RLR Gene Families across Lophotrochozoans: Domain Grafting, Exon–Intron Structure, Expression, and Positive Selection
por: Yao, Shanshan, et al.
Publicado: (2022)

Preliminary investigations on the role of Drp-1 dependent mitochondrial fission in attenuating RLR downstream signaling during nervous necrosis virus infection
por: Krishnan, Rahul, et al.
Publicado: (2018)

Transmissible gastroenteritis virus infection induces NF-κB activation through RLR-mediated signaling
por: Ding, Zhen, et al.
Publicado: (2017)

TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination
por: Chen, Ya-Yun, et al.
Publicado: (2023)

Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway
por: Jiang, Xuefeng, et al.
Publicado: (2021)

GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome
por: Nie, Ying, et al.
Publicado: (2017)

Regulation of mitochondrial permeability transition pore by PINK1
por: Giaime, Emilie, et al.
Publicado: (2012)

Transcriptional analysis of antiviral small molecule therapeutics as agonists of the RLR pathway
por: Green, R.R., et al.
Publicado: (2016)

RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity
por: Yoshizumi, Takuma, et al.
Publicado: (2017)

Potential of PINK1 and PARKIN Proteins as Biomarkers for Active Multiple Sclerosis: A Japanese Cohort Study
por: Cossu, Davide, et al.
Publicado: (2021)

PINK1 cleavage at position A103 by the mitochondrial protease PARL
por: Deas, Emma, et al.
Publicado: (2011)

Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription
por: Zhao, Ningning, et al.
Publicado: (2022)

Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-κB signaling by targeting MAVS complex
por: Cao, Zhongying, et al.
Publicado: (2016)

Regulation of mitochondrial function by PINK1, Parkin and DJ-1
por: Giaime, Emilie, et al.
Publicado: (2013)

SIAH proteins regulate the degradation and intra‐mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease
por: Abd Elghani, Fatimah, et al.
Publicado: (2022)

The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection
por: Vogel, Olivia A., et al.
Publicado: (2020)

O-Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity
por: Seo, Junghwa, et al.
Publicado: (2021)

Temporal integration of mitochondrial stress signals by the PINK1:Parkin pathway
por: Bowling, J. Logan, et al.
Publicado: (2019)

USP4 positively regulates RLR-induced NF-κB activation by targeting TRAF6 for K48-linked deubiquitination and inhibits enterovirus 71 replication
por: Xu, Chao, et al.
Publicado: (2018)

PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control
por: Zhuang, Na, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tmjdt36tv6vfuaaebk384sghkj