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Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD
Gastrointestinal (GI) homeostasis is strongly dependent on nuclear receptor (NR) functions. They play a variety of roles ranging from nutrient uptake, sensing of microbial metabolites, regulation of epithelial intestinal cell integrity to shaping of the intestinal immune cell repertoire. Several NRs...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527601/ https://www.ncbi.nlm.nih.gov/pubmed/31139192 http://dx.doi.org/10.3389/fimmu.2019.01070 |
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author | Klepsch, Victoria Moschen, Alexander R. Tilg, Herbert Baier, Gottfried Hermann-Kleiter, Natascha |
author_facet | Klepsch, Victoria Moschen, Alexander R. Tilg, Herbert Baier, Gottfried Hermann-Kleiter, Natascha |
author_sort | Klepsch, Victoria |
collection | PubMed |
description | Gastrointestinal (GI) homeostasis is strongly dependent on nuclear receptor (NR) functions. They play a variety of roles ranging from nutrient uptake, sensing of microbial metabolites, regulation of epithelial intestinal cell integrity to shaping of the intestinal immune cell repertoire. Several NRs are associated with GI pathologies; therefore, systematic analysis of NR biology, the underlying molecular mechanisms, and regulation of target genes can be expected to help greatly in uncovering the course of GI diseases. Recently, an increasing number of NRs has been validated as potential drug targets for therapeutic intervention in patients with inflammatory bowel disease (IBD). Besides the classical glucocorticoids, especially PPARγ, VDR, or PXR-selective ligands are currently being tested with promising results in clinical IBD trials. Also, several pre-clinical animal studies are being performed with NRs. This review focuses on the complex biology of NRs and their context-dependent anti- or pro-inflammatory activities in the regulation of gastrointestinal barrier with special attention to NRs already pharmacologically targeted in clinic and pre-clinical IBD treatment regimens. |
format | Online Article Text |
id | pubmed-6527601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65276012019-05-28 Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD Klepsch, Victoria Moschen, Alexander R. Tilg, Herbert Baier, Gottfried Hermann-Kleiter, Natascha Front Immunol Immunology Gastrointestinal (GI) homeostasis is strongly dependent on nuclear receptor (NR) functions. They play a variety of roles ranging from nutrient uptake, sensing of microbial metabolites, regulation of epithelial intestinal cell integrity to shaping of the intestinal immune cell repertoire. Several NRs are associated with GI pathologies; therefore, systematic analysis of NR biology, the underlying molecular mechanisms, and regulation of target genes can be expected to help greatly in uncovering the course of GI diseases. Recently, an increasing number of NRs has been validated as potential drug targets for therapeutic intervention in patients with inflammatory bowel disease (IBD). Besides the classical glucocorticoids, especially PPARγ, VDR, or PXR-selective ligands are currently being tested with promising results in clinical IBD trials. Also, several pre-clinical animal studies are being performed with NRs. This review focuses on the complex biology of NRs and their context-dependent anti- or pro-inflammatory activities in the regulation of gastrointestinal barrier with special attention to NRs already pharmacologically targeted in clinic and pre-clinical IBD treatment regimens. Frontiers Media S.A. 2019-05-14 /pmc/articles/PMC6527601/ /pubmed/31139192 http://dx.doi.org/10.3389/fimmu.2019.01070 Text en Copyright © 2019 Klepsch, Moschen, Tilg, Baier and Hermann-Kleiter. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Klepsch, Victoria Moschen, Alexander R. Tilg, Herbert Baier, Gottfried Hermann-Kleiter, Natascha Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD |
title | Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD |
title_full | Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD |
title_fullStr | Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD |
title_full_unstemmed | Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD |
title_short | Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD |
title_sort | nuclear receptors regulate intestinal inflammation in the context of ibd |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527601/ https://www.ncbi.nlm.nih.gov/pubmed/31139192 http://dx.doi.org/10.3389/fimmu.2019.01070 |
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