Cargando…
Content validity and psychometric evaluation of Functional Assessment of Chronic Illness Therapy-Fatigue in patients with psoriatic arthritis
BACKGROUND: To evaluate the measurement properties (e.g., content validity, reliability, and ability to detect change) of the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale in patients with active psoriatic arthritis (PsA). METHODS: One-on-one semi-structured qualitative inte...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527714/ https://www.ncbi.nlm.nih.gov/pubmed/31111255 http://dx.doi.org/10.1186/s41687-019-0115-4 |
_version_ | 1783420070259589120 |
---|---|
author | Cella, David Wilson, Hilary Shalhoub, Huda Revicki, Dennis A. Cappelleri, Joseph C. Bushmakin, Andrew G. Kudlacz, Elizabeth Hsu, Ming-Ann |
author_facet | Cella, David Wilson, Hilary Shalhoub, Huda Revicki, Dennis A. Cappelleri, Joseph C. Bushmakin, Andrew G. Kudlacz, Elizabeth Hsu, Ming-Ann |
author_sort | Cella, David |
collection | PubMed |
description | BACKGROUND: To evaluate the measurement properties (e.g., content validity, reliability, and ability to detect change) of the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale in patients with active psoriatic arthritis (PsA). METHODS: One-on-one semi-structured qualitative interviews with adult patients with active PsA evaluated the content validity of FACIT-Fatigue. Quantitative measurement properties were evaluated using data from phase III tofacitinib randomized controlled trials (RCTs) in PsA: OPAL Broaden (NCT01877668) and OPAL Beyond (NCT01882439). RESULTS: Of 12 patients included in the qualitative study, 2 (17%) had mild, 8 (67%) had moderate, and 2 (17%) had severe PsA disease activity; 7 (58%) attributed fatigue to PsA, and 7 (58%) rated fatigue as important or extremely important. Most patients considered the FACIT-Fatigue items relevant to their PsA experience, and understood item content and response options as intended. In the psychometric analysis of RCT data, a second-order confirmatory factor model fit the data well (Bentler’s Comparative Fit Index ≥0.92). FACIT-Fatigue demonstrated good internal consistency (Cronbach’s coefficient α ≥ 0.90), test-retest reliability (Intraclass Correlation Coefficient ≥ 0.80) and a strong correlation with SF-36 Vitality (r > 0.80). A robust relationship between disease activity (based on Patient’s Global Assessment of Psoriasis and Arthritis) and FACIT-Fatigue was observed (effect sizes > 1.4), with clinically important difference for the FACIT-Fatigue total score estimated as 3.1 points, and the responder definition estimated as a 4-point improvement for FACIT-Fatigue total score. CONCLUSION: Fatigue was confirmed to be an important symptom to patients with PsA, and FACIT-Fatigue was found to be a reliable and valid measure in this population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s41687-019-0115-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6527714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-65277142019-06-07 Content validity and psychometric evaluation of Functional Assessment of Chronic Illness Therapy-Fatigue in patients with psoriatic arthritis Cella, David Wilson, Hilary Shalhoub, Huda Revicki, Dennis A. Cappelleri, Joseph C. Bushmakin, Andrew G. Kudlacz, Elizabeth Hsu, Ming-Ann J Patient Rep Outcomes Research BACKGROUND: To evaluate the measurement properties (e.g., content validity, reliability, and ability to detect change) of the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale in patients with active psoriatic arthritis (PsA). METHODS: One-on-one semi-structured qualitative interviews with adult patients with active PsA evaluated the content validity of FACIT-Fatigue. Quantitative measurement properties were evaluated using data from phase III tofacitinib randomized controlled trials (RCTs) in PsA: OPAL Broaden (NCT01877668) and OPAL Beyond (NCT01882439). RESULTS: Of 12 patients included in the qualitative study, 2 (17%) had mild, 8 (67%) had moderate, and 2 (17%) had severe PsA disease activity; 7 (58%) attributed fatigue to PsA, and 7 (58%) rated fatigue as important or extremely important. Most patients considered the FACIT-Fatigue items relevant to their PsA experience, and understood item content and response options as intended. In the psychometric analysis of RCT data, a second-order confirmatory factor model fit the data well (Bentler’s Comparative Fit Index ≥0.92). FACIT-Fatigue demonstrated good internal consistency (Cronbach’s coefficient α ≥ 0.90), test-retest reliability (Intraclass Correlation Coefficient ≥ 0.80) and a strong correlation with SF-36 Vitality (r > 0.80). A robust relationship between disease activity (based on Patient’s Global Assessment of Psoriasis and Arthritis) and FACIT-Fatigue was observed (effect sizes > 1.4), with clinically important difference for the FACIT-Fatigue total score estimated as 3.1 points, and the responder definition estimated as a 4-point improvement for FACIT-Fatigue total score. CONCLUSION: Fatigue was confirmed to be an important symptom to patients with PsA, and FACIT-Fatigue was found to be a reliable and valid measure in this population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s41687-019-0115-4) contains supplementary material, which is available to authorized users. Springer International Publishing 2019-05-20 /pmc/articles/PMC6527714/ /pubmed/31111255 http://dx.doi.org/10.1186/s41687-019-0115-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Cella, David Wilson, Hilary Shalhoub, Huda Revicki, Dennis A. Cappelleri, Joseph C. Bushmakin, Andrew G. Kudlacz, Elizabeth Hsu, Ming-Ann Content validity and psychometric evaluation of Functional Assessment of Chronic Illness Therapy-Fatigue in patients with psoriatic arthritis |
title | Content validity and psychometric evaluation of Functional Assessment of Chronic Illness Therapy-Fatigue in patients with psoriatic arthritis |
title_full | Content validity and psychometric evaluation of Functional Assessment of Chronic Illness Therapy-Fatigue in patients with psoriatic arthritis |
title_fullStr | Content validity and psychometric evaluation of Functional Assessment of Chronic Illness Therapy-Fatigue in patients with psoriatic arthritis |
title_full_unstemmed | Content validity and psychometric evaluation of Functional Assessment of Chronic Illness Therapy-Fatigue in patients with psoriatic arthritis |
title_short | Content validity and psychometric evaluation of Functional Assessment of Chronic Illness Therapy-Fatigue in patients with psoriatic arthritis |
title_sort | content validity and psychometric evaluation of functional assessment of chronic illness therapy-fatigue in patients with psoriatic arthritis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527714/ https://www.ncbi.nlm.nih.gov/pubmed/31111255 http://dx.doi.org/10.1186/s41687-019-0115-4 |
work_keys_str_mv | AT celladavid contentvalidityandpsychometricevaluationoffunctionalassessmentofchronicillnesstherapyfatigueinpatientswithpsoriaticarthritis AT wilsonhilary contentvalidityandpsychometricevaluationoffunctionalassessmentofchronicillnesstherapyfatigueinpatientswithpsoriaticarthritis AT shalhoubhuda contentvalidityandpsychometricevaluationoffunctionalassessmentofchronicillnesstherapyfatigueinpatientswithpsoriaticarthritis AT revickidennisa contentvalidityandpsychometricevaluationoffunctionalassessmentofchronicillnesstherapyfatigueinpatientswithpsoriaticarthritis AT cappellerijosephc contentvalidityandpsychometricevaluationoffunctionalassessmentofchronicillnesstherapyfatigueinpatientswithpsoriaticarthritis AT bushmakinandrewg contentvalidityandpsychometricevaluationoffunctionalassessmentofchronicillnesstherapyfatigueinpatientswithpsoriaticarthritis AT kudlaczelizabeth contentvalidityandpsychometricevaluationoffunctionalassessmentofchronicillnesstherapyfatigueinpatientswithpsoriaticarthritis AT hsumingann contentvalidityandpsychometricevaluationoffunctionalassessmentofchronicillnesstherapyfatigueinpatientswithpsoriaticarthritis |