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Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells

Purpose: Protein levels and activity of the hypoxia-inducible transcription factors HIF-1 and HIF-2 are controlled by hydroxylation of the regulatory alpha chains. Proline hydroxylases (PHDs) target the protein for degradation via the von-Hippel-Lindau (VHL)-ubiquitin-ligase complex, and asparagine...

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Detalles Bibliográficos
Autores principales:	Wohlrab, Christina, Kuiper, Caroline, Vissers, Margreet CM, Phillips, Elisabeth, Robinson, Bridget A, Dachs, Gabi U
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527796/ https://www.ncbi.nlm.nih.gov/pubmed/31192266 http://dx.doi.org/10.2147/HP.S201643

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