Hydroxyurea Improves Spatial Memory and Cognitive Plasticity in Mice and Has a Mild Effect on These Parameters in a Down Syndrome Mouse Model

Down syndrome (DS), a genetic disorder caused by partial or complete triplication of chromosome 21, is the most common genetic cause of intellectual disability. DS mouse models and cell lines display defects in cellular adaptive stress responses including autophagy, unfolded protein response, and mi...

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Detalles Bibliográficos
Autores principales: Brose, Rebecca Deering, Savonenko, Alena, Devenney, Benjamin, Smith, Kirby D., Reeves, Roger H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527804/
https://www.ncbi.nlm.nih.gov/pubmed/31139073
http://dx.doi.org/10.3389/fnagi.2019.00096

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