Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies

The nascent polypeptide-associated complex (NAC) is a conserved ribosome-associated protein biogenesis factor. Whether NAC exerts chaperone activity and whether this function is restricted to de novo protein synthesis is unknown. Here, we demonstrate that NAC directly exerts chaperone activity towar...

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Detalles Bibliográficos
Autores principales: Shen, Koning, Gamerdinger, Martin, Chan, Rebecca, Gense, Karina, Martin, Esther M., Sachs, Nadine, Knight, Patrick D., Schlömer, Renate, Calabrese, Antonio N., Stewart, Katie L., Leiendecker, Lukas, Baghel, Ankit, Radford, Sheena E., Frydman, Judith, Deuerling, Elke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527867/
https://www.ncbi.nlm.nih.gov/pubmed/30982745
http://dx.doi.org/10.1016/j.molcel.2019.03.012

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