MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

The MYC oncoprotein binds to promoter-proximal regions of virtually all transcribed genes and enhances RNA polymerase II (Pol II) function, but its precise mode of action is poorly understood. Using mass spectrometry of both MYC and Pol II complexes, we show here that MYC controls the assembly of Po...

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Detalles Bibliográficos
Autores principales: Baluapuri, Apoorva, Hofstetter, Julia, Dudvarski Stankovic, Nevenka, Endres, Theresa, Bhandare, Pranjali, Vos, Seychelle Monique, Adhikari, Bikash, Schwarz, Jessica Denise, Narain, Ashwin, Vogt, Markus, Wang, Shuang-Yan, Düster, Robert, Jung, Lisa Anna, Vanselow, Jens Thorsten, Wiegering, Armin, Geyer, Matthias, Maric, Hans Michael, Gallant, Peter, Walz, Susanne, Schlosser, Andreas, Cramer, Patrick, Eilers, Martin, Wolf, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527870/
https://www.ncbi.nlm.nih.gov/pubmed/30928206
http://dx.doi.org/10.1016/j.molcel.2019.02.031

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