Cargando…

Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder

Alterations in large-scale brain intrinsic functional connectivity (FC), i.e., coherence between fluctuations of ongoing activity, have been implicated in major depressive disorder (MDD). Yet, little is known about the frequency-dependent alterations of FC in MDD. We calculated frequency specific de...

Descripción completa

Detalles Bibliográficos
Autores principales: Ries, Anja, Hollander, Matthew, Glim, Sarah, Meng, Chun, Sorg, Christian, Wohlschläger, Afra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527901/
https://www.ncbi.nlm.nih.gov/pubmed/31156409
http://dx.doi.org/10.3389/fnhum.2019.00146
_version_ 1783420109301219328
author Ries, Anja
Hollander, Matthew
Glim, Sarah
Meng, Chun
Sorg, Christian
Wohlschläger, Afra
author_facet Ries, Anja
Hollander, Matthew
Glim, Sarah
Meng, Chun
Sorg, Christian
Wohlschläger, Afra
author_sort Ries, Anja
collection PubMed
description Alterations in large-scale brain intrinsic functional connectivity (FC), i.e., coherence between fluctuations of ongoing activity, have been implicated in major depressive disorder (MDD). Yet, little is known about the frequency-dependent alterations of FC in MDD. We calculated frequency specific degree centrality (DC) – a measure of overall FC of a brain region – within 10 distinct frequency sub-bands accessible from the full range of resting-state fMRI BOLD fluctuations (i.e., 0.01–0.25 Hz) in 24 healthy controls and 24 MDD patients. In healthy controls, results reveal a frequency-specific spatial distribution of highly connected brain regions – i.e., hubs – which play a fundamental role in information integration in the brain. MDD patients exhibited significant deviations from the healthy DC patterns, with decreased overall connectedness of widespread regions, in a frequency-specific manner. Decreased DC in MDD patients was observed predominantly in the occipital cortex at low frequencies (0.01–0.1 Hz), in the middle cingulate cortex, sensorimotor cortex, lateral parietal cortex, and the precuneus at middle frequencies (0.1–0.175 Hz), and in the anterior cingulate cortex at high frequencies (0.175–0.25 Hz). Additionally, decreased DC of distinct parts of the insula was observed across low, middle, and high frequency bands. Frequency-specific alterations in the DC of the temporal, insular, and lateral parietal cortices correlated with symptom severity. Importantly, our results indicate that frequency-resolved analysis within the full range of frequencies accessible from the BOLD signal – also including higher frequencies (>0.1 Hz) – reveals unique information about brain organization and its changes, which can otherwise be overlooked.
format Online
Article
Text
id pubmed-6527901
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-65279012019-05-31 Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder Ries, Anja Hollander, Matthew Glim, Sarah Meng, Chun Sorg, Christian Wohlschläger, Afra Front Hum Neurosci Neuroscience Alterations in large-scale brain intrinsic functional connectivity (FC), i.e., coherence between fluctuations of ongoing activity, have been implicated in major depressive disorder (MDD). Yet, little is known about the frequency-dependent alterations of FC in MDD. We calculated frequency specific degree centrality (DC) – a measure of overall FC of a brain region – within 10 distinct frequency sub-bands accessible from the full range of resting-state fMRI BOLD fluctuations (i.e., 0.01–0.25 Hz) in 24 healthy controls and 24 MDD patients. In healthy controls, results reveal a frequency-specific spatial distribution of highly connected brain regions – i.e., hubs – which play a fundamental role in information integration in the brain. MDD patients exhibited significant deviations from the healthy DC patterns, with decreased overall connectedness of widespread regions, in a frequency-specific manner. Decreased DC in MDD patients was observed predominantly in the occipital cortex at low frequencies (0.01–0.1 Hz), in the middle cingulate cortex, sensorimotor cortex, lateral parietal cortex, and the precuneus at middle frequencies (0.1–0.175 Hz), and in the anterior cingulate cortex at high frequencies (0.175–0.25 Hz). Additionally, decreased DC of distinct parts of the insula was observed across low, middle, and high frequency bands. Frequency-specific alterations in the DC of the temporal, insular, and lateral parietal cortices correlated with symptom severity. Importantly, our results indicate that frequency-resolved analysis within the full range of frequencies accessible from the BOLD signal – also including higher frequencies (>0.1 Hz) – reveals unique information about brain organization and its changes, which can otherwise be overlooked. Frontiers Media S.A. 2019-05-14 /pmc/articles/PMC6527901/ /pubmed/31156409 http://dx.doi.org/10.3389/fnhum.2019.00146 Text en Copyright © 2019 Ries, Hollander, Glim, Meng, Sorg and Wohlschläger. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ries, Anja
Hollander, Matthew
Glim, Sarah
Meng, Chun
Sorg, Christian
Wohlschläger, Afra
Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder
title Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder
title_full Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder
title_fullStr Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder
title_full_unstemmed Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder
title_short Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder
title_sort frequency-dependent spatial distribution of functional hubs in the human brain and alterations in major depressive disorder
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527901/
https://www.ncbi.nlm.nih.gov/pubmed/31156409
http://dx.doi.org/10.3389/fnhum.2019.00146
work_keys_str_mv AT riesanja frequencydependentspatialdistributionoffunctionalhubsinthehumanbrainandalterationsinmajordepressivedisorder
AT hollandermatthew frequencydependentspatialdistributionoffunctionalhubsinthehumanbrainandalterationsinmajordepressivedisorder
AT glimsarah frequencydependentspatialdistributionoffunctionalhubsinthehumanbrainandalterationsinmajordepressivedisorder
AT mengchun frequencydependentspatialdistributionoffunctionalhubsinthehumanbrainandalterationsinmajordepressivedisorder
AT sorgchristian frequencydependentspatialdistributionoffunctionalhubsinthehumanbrainandalterationsinmajordepressivedisorder
AT wohlschlagerafra frequencydependentspatialdistributionoffunctionalhubsinthehumanbrainandalterationsinmajordepressivedisorder