Cargando…
Does restaging transurethral resection of bladder tumour influence outcomes in patients treated with BCG immunotherapy? 491 cases in 20 years’ experience
INTRODUCTION: Bladder cancer is one of the most common malignancies worldwide. AIM: To analyse the influence of restaging transurethral resection of bladder tumour (reTURB) on outcomes in patients treated with BCG immunotherapy. MATERIAL AND METHODS: We analysed a database of 491 patients who were t...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528127/ https://www.ncbi.nlm.nih.gov/pubmed/31118996 http://dx.doi.org/10.5114/wiitm.2018.79993 |
_version_ | 1783420152584339456 |
---|---|
author | Krajewski, Wojciech Zdrojowy, Romuald Kościelska-Kasprzak, Katarzyna Dembowski, Janusz Wróbel, Michał Łuczak, Mateusz Kołodziej, Anna |
author_facet | Krajewski, Wojciech Zdrojowy, Romuald Kościelska-Kasprzak, Katarzyna Dembowski, Janusz Wróbel, Michał Łuczak, Mateusz Kołodziej, Anna |
author_sort | Krajewski, Wojciech |
collection | PubMed |
description | INTRODUCTION: Bladder cancer is one of the most common malignancies worldwide. AIM: To analyse the influence of restaging transurethral resection of bladder tumour (reTURB) on outcomes in patients treated with BCG immunotherapy. MATERIAL AND METHODS: We analysed a database of 491 patients who were treated in a Bacillus Calmette-Guérin (BCG) outpatient department between 1998 and 2016. A minimum of 12 months of follow-up was required. The study included 235 patients with a history of the reTURB procedure and 256 patients without reTURB. The patients were analysed in terms of recurrence-free (RFS), progression-free (PFS), cancer-specific and overall survival. RESULTS: The RFS was significantly higher in the reTURB group for both general and subgroup analysis (T1HG, TaHG). The PFS was significantly higher in the reTURB group for both general and subgroup analysis (TaHG). In patients without lamina muscularis in the specimen there was a greater improvement in RFS due to the reTURB procedure than for other patients. ReTURB performed in T1 tumours with massive lamina propria infiltration had a positive influence on RFS. In patients with reTURB the presence of focal invasion was related to lower risk of progression. Both overall and cancer-specific survival were significantly improved by the reTURB procedure in T1HG and HG tumours. CONCLUSIONS: This study highlights the importance of reTURB. It was found that the patients with TaHG tumours benefited the most in terms of RFS, PFS and cancer-specific survival. It was also demonstrated that massive lamina propria infiltration in T1 tumours is associated with the worst outcomes. |
format | Online Article Text |
id | pubmed-6528127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-65281272019-05-22 Does restaging transurethral resection of bladder tumour influence outcomes in patients treated with BCG immunotherapy? 491 cases in 20 years’ experience Krajewski, Wojciech Zdrojowy, Romuald Kościelska-Kasprzak, Katarzyna Dembowski, Janusz Wróbel, Michał Łuczak, Mateusz Kołodziej, Anna Wideochir Inne Tech Maloinwazyjne Original Paper INTRODUCTION: Bladder cancer is one of the most common malignancies worldwide. AIM: To analyse the influence of restaging transurethral resection of bladder tumour (reTURB) on outcomes in patients treated with BCG immunotherapy. MATERIAL AND METHODS: We analysed a database of 491 patients who were treated in a Bacillus Calmette-Guérin (BCG) outpatient department between 1998 and 2016. A minimum of 12 months of follow-up was required. The study included 235 patients with a history of the reTURB procedure and 256 patients without reTURB. The patients were analysed in terms of recurrence-free (RFS), progression-free (PFS), cancer-specific and overall survival. RESULTS: The RFS was significantly higher in the reTURB group for both general and subgroup analysis (T1HG, TaHG). The PFS was significantly higher in the reTURB group for both general and subgroup analysis (TaHG). In patients without lamina muscularis in the specimen there was a greater improvement in RFS due to the reTURB procedure than for other patients. ReTURB performed in T1 tumours with massive lamina propria infiltration had a positive influence on RFS. In patients with reTURB the presence of focal invasion was related to lower risk of progression. Both overall and cancer-specific survival were significantly improved by the reTURB procedure in T1HG and HG tumours. CONCLUSIONS: This study highlights the importance of reTURB. It was found that the patients with TaHG tumours benefited the most in terms of RFS, PFS and cancer-specific survival. It was also demonstrated that massive lamina propria infiltration in T1 tumours is associated with the worst outcomes. Termedia Publishing House 2018-12-19 2019-04 /pmc/articles/PMC6528127/ /pubmed/31118996 http://dx.doi.org/10.5114/wiitm.2018.79993 Text en Copyright: © 2018 Fundacja Videochirurgii http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Krajewski, Wojciech Zdrojowy, Romuald Kościelska-Kasprzak, Katarzyna Dembowski, Janusz Wróbel, Michał Łuczak, Mateusz Kołodziej, Anna Does restaging transurethral resection of bladder tumour influence outcomes in patients treated with BCG immunotherapy? 491 cases in 20 years’ experience |
title | Does restaging transurethral resection of bladder tumour influence outcomes in patients treated with BCG immunotherapy? 491 cases in 20 years’ experience |
title_full | Does restaging transurethral resection of bladder tumour influence outcomes in patients treated with BCG immunotherapy? 491 cases in 20 years’ experience |
title_fullStr | Does restaging transurethral resection of bladder tumour influence outcomes in patients treated with BCG immunotherapy? 491 cases in 20 years’ experience |
title_full_unstemmed | Does restaging transurethral resection of bladder tumour influence outcomes in patients treated with BCG immunotherapy? 491 cases in 20 years’ experience |
title_short | Does restaging transurethral resection of bladder tumour influence outcomes in patients treated with BCG immunotherapy? 491 cases in 20 years’ experience |
title_sort | does restaging transurethral resection of bladder tumour influence outcomes in patients treated with bcg immunotherapy? 491 cases in 20 years’ experience |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528127/ https://www.ncbi.nlm.nih.gov/pubmed/31118996 http://dx.doi.org/10.5114/wiitm.2018.79993 |
work_keys_str_mv | AT krajewskiwojciech doesrestagingtransurethralresectionofbladdertumourinfluenceoutcomesinpatientstreatedwithbcgimmunotherapy491casesin20yearsexperience AT zdrojowyromuald doesrestagingtransurethralresectionofbladdertumourinfluenceoutcomesinpatientstreatedwithbcgimmunotherapy491casesin20yearsexperience AT koscielskakasprzakkatarzyna doesrestagingtransurethralresectionofbladdertumourinfluenceoutcomesinpatientstreatedwithbcgimmunotherapy491casesin20yearsexperience AT dembowskijanusz doesrestagingtransurethralresectionofbladdertumourinfluenceoutcomesinpatientstreatedwithbcgimmunotherapy491casesin20yearsexperience AT wrobelmichał doesrestagingtransurethralresectionofbladdertumourinfluenceoutcomesinpatientstreatedwithbcgimmunotherapy491casesin20yearsexperience AT łuczakmateusz doesrestagingtransurethralresectionofbladdertumourinfluenceoutcomesinpatientstreatedwithbcgimmunotherapy491casesin20yearsexperience AT kołodziejanna doesrestagingtransurethralresectionofbladdertumourinfluenceoutcomesinpatientstreatedwithbcgimmunotherapy491casesin20yearsexperience |