Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader

[Image: see text] Inducing post-translational protein knockdown is an important approach to probe biology and validate drug targets. An efficient strategy to achieve this involves expression of a protein of interest fused to an exogenous tag, allowing tag-directed chemical degraders to mediate prote...

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Detalles Bibliográficos
Autores principales: Tovell, Hannah, Testa, Andrea, Maniaci, Chiara, Zhou, Houjiang, Prescott, Alan R, Macartney, Thomas, Ciulli, Alessio, Alessi, Dario R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528276/
https://www.ncbi.nlm.nih.gov/pubmed/30978004
http://dx.doi.org/10.1021/acschembio.8b01016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528276/
https://www.ncbi.nlm.nih.gov/pubmed/30978004
http://dx.doi.org/10.1021/acschembio.8b01016

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