Cargando…

Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures

BACKGROUND: Small cell lung cancer (SCLC) is usually diagnosed in the advanced stage. It has a very poor prognosis, with no advancements in therapy in the last few decades. A recent phase 1 clinical study, using an antibody-drug conjugate directed against DLL3, showed promising results. A prerequisi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brcic, Luka, Kuchler, Christian, Eidenhammer, Sylvia, Pabst, Daniela, Quehenberger, Franz, Gazdar, Adi F., Popper, Helmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528329/ https://www.ncbi.nlm.nih.gov/pubmed/31109352 http://dx.doi.org/10.1186/s13000-019-0827-z

Ejemplares similares

Bulk tumour cell migration in lung carcinomas might be more common than epithelial-mesenchymal transition and be differently regulated
por: Zacharias, Martin, et al.
Publicado: (2018)

Senescence and autophagy in usual interstitial pneumonia of different etiology
por: Gallob, Florian, et al.
Publicado: (2020)

Pleuropulmonary blastoma type I might arise in congenital pulmonary airway malformation type 4 by acquiring a Dicer 1 mutation
por: Brcic, Luka, et al.
Publicado: (2020)

Diagnosis and Molecular Profiles of Large Cell Neuroendocrine Carcinoma With Potential Targets for Therapy
por: Popper, Helmut, et al.
Publicado: (2021)

DLL3 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms
por: Yao, James, et al.
Publicado: (2022)

Novel stereotactic body radiation therapy (SBRT)-based partial tumor irradiation targeting hypoxic segment of bulky tumors (SBRT-PATHY): improvement of the radiotherapy outcome by exploiting the bystander and abscopal effects
por: Tubin, Slavisa, et al.
Publicado: (2019)

Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer
por: Smolle, Elisabeth, et al.
Publicado: (2020)

Lung fibrosis in autoimmune diseases and hypersensitivity: how to separate these from idiopathic pulmonary fibrosis
por: Popper, Helmut, et al.
Publicado: (2021)

Applicability of pan-TRK immunohistochemistry for identification of NTRK fusions in lung carcinoma
por: Strohmeier, Simon, et al.
Publicado: (2021)

Immune cell landscape in therapy-naïve squamous cell and adenocarcinomas of the lung
por: Brcic, Luka, et al.
Publicado: (2018)

Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
por: Geffers, Insa, et al.
Publicado: (2007)

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo
por: Preuße, Kristina, et al.
Publicado: (2015)

Primary patient-derived lung adenocarcinoma cell culture challenges the association of cancer stem cells with epithelial-to-mesenchymal transition
por: Tiran, Verena, et al.
Publicado: (2017)

Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine
por: Shimizu, Hiromichi, et al.
Publicado: (2014)

Analysis of the frequency of EGFR, KRAS and ALK mutations in patients with lung adenocarcinoma in Croatia
por: Brcic, Luka, et al.
Publicado: (2016)

Normal Development in Mice Over-Expressing the Intracellular Domain of DLL1 Argues against Reverse Signaling by DLL1 In Vivo
por: Redeker, Christian, et al.
Publicado: (2013)

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro
por: Tveriakhina, Lena, et al.
Publicado: (2018)

Clinical implications of DLL4 expression in gastric cancer
por: Ishigami, Sumiya, et al.
Publicado: (2013)

Challenges in High-grade Neuroendocrine Neoplasms and Mixed Neuroendocrine/Non-neuroendocrine Neoplasms
por: La Rosa, Stefano
Publicado: (2021)

miR375-3p Distinguishes Low-Grade Neuroendocrine From Non-neuroendocrine Lung Tumors in FFPE Samples
por: Detassis, Simone, et al.
Publicado: (2020)

Therapeutic promise and challenges of targeting DLL4/NOTCH1
por: Yan, Minhong
Publicado: (2011)

DLL3: an emerging target in small cell lung cancer
por: Owen, Dwight H., et al.
Publicado: (2019)

Maintenance of Bone Homeostasis by DLL1‐Mediated Notch Signaling
por: Muguruma, Yukari, et al.
Publicado: (2017)

Dll1 haploinsufficiency causes brain abnormalities with functional relevance
por: Arzate, Dulce-María, et al.
Publicado: (2022)

The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions
por: Lobov, Ivan, et al.
Publicado: (2018)

Low Grade Neuroendocrine Tumors of the Lung
por: Melosky, Barbara
Publicado: (2017)

CT perfusion imaging of the liver and the spleen in patients with cirrhosis: Is there a correlation between perfusion and portal venous hypertension?
por: Talakić, Emina, et al.
Publicado: (2017)

Anti-DLL4, a cancer therapeutic with multiple mechanisms of action
por: Gurney, Austin, et al.
Publicado: (2011)

Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
por: Kuhnert, Frank, et al.
Publicado: (2011)

The Regulation of para-Nitrophenol Degradation in Pseudomonas putida DLL-E4
por: Chen, Qiongzhen, et al.
Publicado: (2016)

O-Fucosylation of DLL3 Is Required for Its Function during Somitogenesis
por: Serth, Katrin, et al.
Publicado: (2015)

MPDZ promotes DLL4-induced Notch signaling during angiogenesis
por: Tetzlaff, Fabian, et al.
Publicado: (2018)

The role of DLL1 in long-term vascular normalization and cancer immunotherapy
por: Wu, Qiaozhen, et al.
Publicado: (2021)

DLL3 regulates Notch signaling in small cell lung cancer
por: Kim, Jun W., et al.
Publicado: (2022)

Increased incidence trend of low-grade and high-grade neuroendocrine neoplasms
por: Leoncini, Emanuele, et al.
Publicado: (2017)

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors
por: He, Min, et al.
Publicado: (2018)

SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II–III Diffuse Gliomas
por: Zhang, Yu-An, et al.
Publicado: (2016)

Spatial patterning of the Notch ligand Dll4 controls endothelial sprouting in vitro
por: Tiemeijer, L. A., et al.
Publicado: (2018)

Rovalpituzumab Tesirine: A Novel DLL3-Targeting Antibody–Drug Conjugate
por: Lashari, Bilal H., et al.
Publicado: (2018)

Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer
por: Isobe, Yoshitaka, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_urjmk7qbqv6o1mkb4b70i1l7ec