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Role of Fatty Acids Intake in Generalized Vitiligo

BACKGROUND: Previous studies indicated the effect of fat on autoimmune diseases. The present study was aimed to investigate the association between fat intake and vitiligo. METHODS: This case–control study was conducted in the Skin and Leishmania Research Center, Isfahan University of Medical Scienc...

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Autores principales: Derakhshandeh-Rishehri, Seyedeh-Masomeh, Heidari-Beni, Motahar, Jaffary, Fariba, Askari, Gholamreza, Nilfroshzade, Mohammadali, Adibi, Neda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528431/
https://www.ncbi.nlm.nih.gov/pubmed/31143426
http://dx.doi.org/10.4103/ijpvm.IJPVM_47_17
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author Derakhshandeh-Rishehri, Seyedeh-Masomeh
Heidari-Beni, Motahar
Jaffary, Fariba
Askari, Gholamreza
Nilfroshzade, Mohammadali
Adibi, Neda
author_facet Derakhshandeh-Rishehri, Seyedeh-Masomeh
Heidari-Beni, Motahar
Jaffary, Fariba
Askari, Gholamreza
Nilfroshzade, Mohammadali
Adibi, Neda
author_sort Derakhshandeh-Rishehri, Seyedeh-Masomeh
collection PubMed
description BACKGROUND: Previous studies indicated the effect of fat on autoimmune diseases. The present study was aimed to investigate the association between fat intake and vitiligo. METHODS: This case–control study was conducted in the Skin and Leishmania Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Intakes of fatty acids were examined for their relation to risk of vitiligo among 100 cases and 110 controls. We included patients who suffered from generalized or localized vitiligo for <5 years that was approved by a dermatologist via the Vitiligo European Task Force criteria and the vitiligo area scoring index. Fat intake was assessed through individual interviews by a standardized food frequency questionnaire. RESULTS: Vitiligo group consumed more saturated fatty acid (SFA) and less eicosapentaenoic acid and docosahexaenoic acid than control group, while other fatty acids were not significantly different among two groups (P > 0.05). Crude analysis showed that total fat (odds ratio [OR] = 3.33, 95% confidence interval [CI]: 1.46–7.58) and SFA (OR = 2.22, 95% CI: 1.04–4.90) intakes were associated with an increased risk of vitiligo (for highest quartile vs. lowest quartile). Results demonstrated a decrease in the risk of vitiligo for those within the highest quartile of monounsaturated fatty acids intake (OR = 0.41, 95% CI: 0.18–0.92). However, this relationship disappeared after adjustment for confounders as energy, age, sex, and body mass index, except for total fat (OR = 2.84, 95% CI: 1.63–5.44). Crude and adjusted analyses for polyunsaturated fatty acids and cholesterol intake were not statistically significant. CONCLUSIONS: Total-fat content of the diet had more impressive role than the specific subclasses of fats on the incidence risk of vitiligo. High-fat diet escalated the vitiligo risk. Regarding the role of fats on skin autoimmune diseases especially vitiligo, future studies are crucial.
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spelling pubmed-65284312019-05-29 Role of Fatty Acids Intake in Generalized Vitiligo Derakhshandeh-Rishehri, Seyedeh-Masomeh Heidari-Beni, Motahar Jaffary, Fariba Askari, Gholamreza Nilfroshzade, Mohammadali Adibi, Neda Int J Prev Med Original Article BACKGROUND: Previous studies indicated the effect of fat on autoimmune diseases. The present study was aimed to investigate the association between fat intake and vitiligo. METHODS: This case–control study was conducted in the Skin and Leishmania Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Intakes of fatty acids were examined for their relation to risk of vitiligo among 100 cases and 110 controls. We included patients who suffered from generalized or localized vitiligo for <5 years that was approved by a dermatologist via the Vitiligo European Task Force criteria and the vitiligo area scoring index. Fat intake was assessed through individual interviews by a standardized food frequency questionnaire. RESULTS: Vitiligo group consumed more saturated fatty acid (SFA) and less eicosapentaenoic acid and docosahexaenoic acid than control group, while other fatty acids were not significantly different among two groups (P > 0.05). Crude analysis showed that total fat (odds ratio [OR] = 3.33, 95% confidence interval [CI]: 1.46–7.58) and SFA (OR = 2.22, 95% CI: 1.04–4.90) intakes were associated with an increased risk of vitiligo (for highest quartile vs. lowest quartile). Results demonstrated a decrease in the risk of vitiligo for those within the highest quartile of monounsaturated fatty acids intake (OR = 0.41, 95% CI: 0.18–0.92). However, this relationship disappeared after adjustment for confounders as energy, age, sex, and body mass index, except for total fat (OR = 2.84, 95% CI: 1.63–5.44). Crude and adjusted analyses for polyunsaturated fatty acids and cholesterol intake were not statistically significant. CONCLUSIONS: Total-fat content of the diet had more impressive role than the specific subclasses of fats on the incidence risk of vitiligo. High-fat diet escalated the vitiligo risk. Regarding the role of fats on skin autoimmune diseases especially vitiligo, future studies are crucial. Wolters Kluwer - Medknow 2019-05-06 /pmc/articles/PMC6528431/ /pubmed/31143426 http://dx.doi.org/10.4103/ijpvm.IJPVM_47_17 Text en Copyright: © 2019 International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Derakhshandeh-Rishehri, Seyedeh-Masomeh
Heidari-Beni, Motahar
Jaffary, Fariba
Askari, Gholamreza
Nilfroshzade, Mohammadali
Adibi, Neda
Role of Fatty Acids Intake in Generalized Vitiligo
title Role of Fatty Acids Intake in Generalized Vitiligo
title_full Role of Fatty Acids Intake in Generalized Vitiligo
title_fullStr Role of Fatty Acids Intake in Generalized Vitiligo
title_full_unstemmed Role of Fatty Acids Intake in Generalized Vitiligo
title_short Role of Fatty Acids Intake in Generalized Vitiligo
title_sort role of fatty acids intake in generalized vitiligo
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528431/
https://www.ncbi.nlm.nih.gov/pubmed/31143426
http://dx.doi.org/10.4103/ijpvm.IJPVM_47_17
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