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The Incidence of Cystic Fibrosis in the Central Region of Anatolia in Turkey Between 2015 and 2016

BACKGROUND: Cystic fibrosis is the most common metabolic chronic disease among European Caucasian children. Cystic fibrosis incidence in Northern Europeans countries is approximately 1 in 3000 births while the worldwide prevalence varies considerably. AIMS: To determine the incidence of cystic fibro...

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Autores principales: Hangül, Melih, Pekcan, Sevgi, Köse, Mehmet, Acıcan, Deniz, Şahlar, Tuba Esra, Erdoğan, Murat, Kendirci, Mustafa, Güney, Deniz, Öznavruz, Hasan, Demir, Osman, Ercan, Ömür, Göçlü, Fatma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528529/
https://www.ncbi.nlm.nih.gov/pubmed/30592194
http://dx.doi.org/10.4274/balkanmedj.galenos.2018.2018.1332
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author Hangül, Melih
Pekcan, Sevgi
Köse, Mehmet
Acıcan, Deniz
Şahlar, Tuba Esra
Erdoğan, Murat
Kendirci, Mustafa
Güney, Deniz
Öznavruz, Hasan
Demir, Osman
Ercan, Ömür
Göçlü, Fatma
author_facet Hangül, Melih
Pekcan, Sevgi
Köse, Mehmet
Acıcan, Deniz
Şahlar, Tuba Esra
Erdoğan, Murat
Kendirci, Mustafa
Güney, Deniz
Öznavruz, Hasan
Demir, Osman
Ercan, Ömür
Göçlü, Fatma
author_sort Hangül, Melih
collection PubMed
description BACKGROUND: Cystic fibrosis is the most common metabolic chronic disease among European Caucasian children. Cystic fibrosis incidence in Northern Europeans countries is approximately 1 in 3000 births while the worldwide prevalence varies considerably. AIMS: To determine the incidence of cystic fibrosis in the central region of Anatolia in Turkey using the newborn screening program data. STUDY DESIGN: Cross-sectional study. METHODS: We used the records of the newborn screening program which is implemented by the Konya and Kayseri Provincial Health Directories. Between January 2015 and December 2016, there were a total of 119006 live births in Konya and Kayseri. The newborn screening test was applied to all these babies. RESULTS: During this period, there were 22 live born babies diagnosed with cystic fibrosis in Konya with an incidence of 2.9 per 10000 live births and 13 live born babies diagnosed with cystic fibrosis in Kayseri with an incidence of 2.8 per 10000 live births. In genetic of 30 patients, fifteen patients were homozygous, and 15 patients were a compound heterozygote. Twenty-one different gene variants were detected and the most common mutation was F508del (17/30). CONCLUSION: We found the incidence of cystic fibrosis in central Anatolia similar to northern European countries.
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spelling pubmed-65285292019-05-30 The Incidence of Cystic Fibrosis in the Central Region of Anatolia in Turkey Between 2015 and 2016 Hangül, Melih Pekcan, Sevgi Köse, Mehmet Acıcan, Deniz Şahlar, Tuba Esra Erdoğan, Murat Kendirci, Mustafa Güney, Deniz Öznavruz, Hasan Demir, Osman Ercan, Ömür Göçlü, Fatma Balkan Med J Original Article BACKGROUND: Cystic fibrosis is the most common metabolic chronic disease among European Caucasian children. Cystic fibrosis incidence in Northern Europeans countries is approximately 1 in 3000 births while the worldwide prevalence varies considerably. AIMS: To determine the incidence of cystic fibrosis in the central region of Anatolia in Turkey using the newborn screening program data. STUDY DESIGN: Cross-sectional study. METHODS: We used the records of the newborn screening program which is implemented by the Konya and Kayseri Provincial Health Directories. Between January 2015 and December 2016, there were a total of 119006 live births in Konya and Kayseri. The newborn screening test was applied to all these babies. RESULTS: During this period, there were 22 live born babies diagnosed with cystic fibrosis in Konya with an incidence of 2.9 per 10000 live births and 13 live born babies diagnosed with cystic fibrosis in Kayseri with an incidence of 2.8 per 10000 live births. In genetic of 30 patients, fifteen patients were homozygous, and 15 patients were a compound heterozygote. Twenty-one different gene variants were detected and the most common mutation was F508del (17/30). CONCLUSION: We found the incidence of cystic fibrosis in central Anatolia similar to northern European countries. Galenos Publishing 2019-05 2019-05-10 /pmc/articles/PMC6528529/ /pubmed/30592194 http://dx.doi.org/10.4274/balkanmedj.galenos.2018.2018.1332 Text en ©Copyright 2019 by Trakya University Faculty of Medicine http://creativecommons.org/licenses/by/2.5/ The Balkan Medical Journal published by Galenos Publishing House.
spellingShingle Original Article
Hangül, Melih
Pekcan, Sevgi
Köse, Mehmet
Acıcan, Deniz
Şahlar, Tuba Esra
Erdoğan, Murat
Kendirci, Mustafa
Güney, Deniz
Öznavruz, Hasan
Demir, Osman
Ercan, Ömür
Göçlü, Fatma
The Incidence of Cystic Fibrosis in the Central Region of Anatolia in Turkey Between 2015 and 2016
title The Incidence of Cystic Fibrosis in the Central Region of Anatolia in Turkey Between 2015 and 2016
title_full The Incidence of Cystic Fibrosis in the Central Region of Anatolia in Turkey Between 2015 and 2016
title_fullStr The Incidence of Cystic Fibrosis in the Central Region of Anatolia in Turkey Between 2015 and 2016
title_full_unstemmed The Incidence of Cystic Fibrosis in the Central Region of Anatolia in Turkey Between 2015 and 2016
title_short The Incidence of Cystic Fibrosis in the Central Region of Anatolia in Turkey Between 2015 and 2016
title_sort incidence of cystic fibrosis in the central region of anatolia in turkey between 2015 and 2016
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528529/
https://www.ncbi.nlm.nih.gov/pubmed/30592194
http://dx.doi.org/10.4274/balkanmedj.galenos.2018.2018.1332
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