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Sexual Functioning and Opioid Maintenance Treatment in Women. Results From a Large Multicentre Study

Opioid maintenance treatment (OMT) is the most widespread therapy for both females and males opioid addicts. While many studies have evaluated the OMT impact on men’s sexuality, the data collected about the change in women’s sexual functioning is still limited despite the fact that it is now well-kn...

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Autores principales: Zamboni, Lorenzo, Franceschini, Anna, Portoghese, Igor, Morbioli, Laura, Lugoboni, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528617/
https://www.ncbi.nlm.nih.gov/pubmed/31156404
http://dx.doi.org/10.3389/fnbeh.2019.00097
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author Zamboni, Lorenzo
Franceschini, Anna
Portoghese, Igor
Morbioli, Laura
Lugoboni, Fabio
author_facet Zamboni, Lorenzo
Franceschini, Anna
Portoghese, Igor
Morbioli, Laura
Lugoboni, Fabio
author_sort Zamboni, Lorenzo
collection PubMed
description Opioid maintenance treatment (OMT) is the most widespread therapy for both females and males opioid addicts. While many studies have evaluated the OMT impact on men’s sexuality, the data collected about the change in women’s sexual functioning is still limited despite the fact that it is now well-known that opioids - both endogenous and exogenous - affect the endocrine system and play an important role in sexual functioning. The present study aims to determine how OMT with buprenorphine (BUP) or methadone (MTD) affects sexual health in women; examining also any possible emerging correlation between sexual dysfunction (SD), type of opioid and patients’ mental health. This multi-center study case recruited 258 female volunteers attending Italian public Addiction Outpatients Centers that were stabilized with OMT for at least 3 months. SD was assessed with the Arizona Sexual Experience Scale. The twelve-item General Health Questionnaire was used to assess participants’ mental health conditions. The results show that 56.6% of women receiving OMT for at least 3 months presented SD without significant differences between MTD e BUP groups. The majority of the subjects with SD have a poorer quality of intimate relationships and worse mental health than the average. To the best of our knowledge, the present study is the largest report on the presence of SDs in women as a side effects of MTD and BUP used in OMT. Since SDs cause difficulties in intimate relationships, lower patients’ quality of life and interfere with OMT beneficial outcomes, we recommend that women undertaking an opioid therapy have routine screening for SD and we highlight the importance to better examine opioid-endocrine interactions in future studies in order to provide alternative potential treatments such as the choice of opioid, opioid dose reduction and hormone supplementation.
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spelling pubmed-65286172019-05-31 Sexual Functioning and Opioid Maintenance Treatment in Women. Results From a Large Multicentre Study Zamboni, Lorenzo Franceschini, Anna Portoghese, Igor Morbioli, Laura Lugoboni, Fabio Front Behav Neurosci Neuroscience Opioid maintenance treatment (OMT) is the most widespread therapy for both females and males opioid addicts. While many studies have evaluated the OMT impact on men’s sexuality, the data collected about the change in women’s sexual functioning is still limited despite the fact that it is now well-known that opioids - both endogenous and exogenous - affect the endocrine system and play an important role in sexual functioning. The present study aims to determine how OMT with buprenorphine (BUP) or methadone (MTD) affects sexual health in women; examining also any possible emerging correlation between sexual dysfunction (SD), type of opioid and patients’ mental health. This multi-center study case recruited 258 female volunteers attending Italian public Addiction Outpatients Centers that were stabilized with OMT for at least 3 months. SD was assessed with the Arizona Sexual Experience Scale. The twelve-item General Health Questionnaire was used to assess participants’ mental health conditions. The results show that 56.6% of women receiving OMT for at least 3 months presented SD without significant differences between MTD e BUP groups. The majority of the subjects with SD have a poorer quality of intimate relationships and worse mental health than the average. To the best of our knowledge, the present study is the largest report on the presence of SDs in women as a side effects of MTD and BUP used in OMT. Since SDs cause difficulties in intimate relationships, lower patients’ quality of life and interfere with OMT beneficial outcomes, we recommend that women undertaking an opioid therapy have routine screening for SD and we highlight the importance to better examine opioid-endocrine interactions in future studies in order to provide alternative potential treatments such as the choice of opioid, opioid dose reduction and hormone supplementation. Frontiers Media S.A. 2019-05-14 /pmc/articles/PMC6528617/ /pubmed/31156404 http://dx.doi.org/10.3389/fnbeh.2019.00097 Text en Copyright © 2019 Zamboni, Franceschini, Portoghese, Morbioli, Lugoboni and GICS Group. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zamboni, Lorenzo
Franceschini, Anna
Portoghese, Igor
Morbioli, Laura
Lugoboni, Fabio
Sexual Functioning and Opioid Maintenance Treatment in Women. Results From a Large Multicentre Study
title Sexual Functioning and Opioid Maintenance Treatment in Women. Results From a Large Multicentre Study
title_full Sexual Functioning and Opioid Maintenance Treatment in Women. Results From a Large Multicentre Study
title_fullStr Sexual Functioning and Opioid Maintenance Treatment in Women. Results From a Large Multicentre Study
title_full_unstemmed Sexual Functioning and Opioid Maintenance Treatment in Women. Results From a Large Multicentre Study
title_short Sexual Functioning and Opioid Maintenance Treatment in Women. Results From a Large Multicentre Study
title_sort sexual functioning and opioid maintenance treatment in women. results from a large multicentre study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528617/
https://www.ncbi.nlm.nih.gov/pubmed/31156404
http://dx.doi.org/10.3389/fnbeh.2019.00097
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