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Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series

OBJECTIVE: To compare clinical characteristics of patients suffering from neovascular age-related macular degeneration (nAMD) with mature and immature choroidal neovascularisation (CNV) as assessed by optical coherence tomography angiography (OCTA). To explore the effect of total anti-vascular endot...

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Autores principales: Faes, Livia, Ali, Zaria, Wagner, Siegfried, Patel, Praveen J, Fu, Dun Jack, Bachmann, Lucas M, Schmid, Martin K, Waheed, Nadia, Keane, Pearse A, Balaskas, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528762/
https://www.ncbi.nlm.nih.gov/pubmed/31179393
http://dx.doi.org/10.1136/bmjophth-2018-000244
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author Faes, Livia
Ali, Zaria
Wagner, Siegfried
Patel, Praveen J
Fu, Dun Jack
Bachmann, Lucas M
Schmid, Martin K
Waheed, Nadia
Keane, Pearse A
Balaskas, Konstantinos
author_facet Faes, Livia
Ali, Zaria
Wagner, Siegfried
Patel, Praveen J
Fu, Dun Jack
Bachmann, Lucas M
Schmid, Martin K
Waheed, Nadia
Keane, Pearse A
Balaskas, Konstantinos
author_sort Faes, Livia
collection PubMed
description OBJECTIVE: To compare clinical characteristics of patients suffering from neovascular age-related macular degeneration (nAMD) with mature and immature choroidal neovascularisation (CNV) as assessed by optical coherence tomography angiography (OCTA). To explore the effect of total anti-vascular endothelial growth factor exposure on the occurrence of mature CNV when correcting for potential confounders. METHODS AND ANALYSIS: In this retrospective case series, we included 40 eyes of 36 patients with nAMD with CNV assessed by OCTA at the Manchester Eye Hospital between June 2016 and June 2017. A retinal specialist masked to patient information graded CNV depicted on OCTA scans. For statistical comparisons, we used t-tests, Fisher’s exact tests and a mixed-effects logistic regression model. RESULTS: 18 patients (20 eyes) were treatment naïve, and the mean number of intravitreal injections (IVI) in the remaining eyes was 18.4 (range 2–71). The mean duration of nAMD was 19.3 months (range 0–87.4). 25 eyes (62.5%) exhibited mature CNV. Eyes with mature CNV did not differ from those with immature CNV regarding age (+2.8 years; p=0.288) or duration of disease (+9.4 months; p=0.061). However, they had a higher number of IVIs (+3.1; p=0.035). Among eyes with best corrected visual acuity over 25 letters, there was a strong association between the number of IVIs (0 vs 1–20: OR 68.01 [95% CI 1.30 to 3546.99; p=0.036], 0 vs >20 IVI: OR 380.01 [95% CI 2.60 to 55 464.89; p=0.019]) and maturity status when correcting for potential confounders. CONCLUSION: Maturity status of CNV as assessed by OCTA may indicate treatment exposure of CNV in nAMD.
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spelling pubmed-65287622019-06-07 Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series Faes, Livia Ali, Zaria Wagner, Siegfried Patel, Praveen J Fu, Dun Jack Bachmann, Lucas M Schmid, Martin K Waheed, Nadia Keane, Pearse A Balaskas, Konstantinos BMJ Open Ophthalmol Original Article OBJECTIVE: To compare clinical characteristics of patients suffering from neovascular age-related macular degeneration (nAMD) with mature and immature choroidal neovascularisation (CNV) as assessed by optical coherence tomography angiography (OCTA). To explore the effect of total anti-vascular endothelial growth factor exposure on the occurrence of mature CNV when correcting for potential confounders. METHODS AND ANALYSIS: In this retrospective case series, we included 40 eyes of 36 patients with nAMD with CNV assessed by OCTA at the Manchester Eye Hospital between June 2016 and June 2017. A retinal specialist masked to patient information graded CNV depicted on OCTA scans. For statistical comparisons, we used t-tests, Fisher’s exact tests and a mixed-effects logistic regression model. RESULTS: 18 patients (20 eyes) were treatment naïve, and the mean number of intravitreal injections (IVI) in the remaining eyes was 18.4 (range 2–71). The mean duration of nAMD was 19.3 months (range 0–87.4). 25 eyes (62.5%) exhibited mature CNV. Eyes with mature CNV did not differ from those with immature CNV regarding age (+2.8 years; p=0.288) or duration of disease (+9.4 months; p=0.061). However, they had a higher number of IVIs (+3.1; p=0.035). Among eyes with best corrected visual acuity over 25 letters, there was a strong association between the number of IVIs (0 vs 1–20: OR 68.01 [95% CI 1.30 to 3546.99; p=0.036], 0 vs >20 IVI: OR 380.01 [95% CI 2.60 to 55 464.89; p=0.019]) and maturity status when correcting for potential confounders. CONCLUSION: Maturity status of CNV as assessed by OCTA may indicate treatment exposure of CNV in nAMD. BMJ Publishing Group 2019-04-09 /pmc/articles/PMC6528762/ /pubmed/31179393 http://dx.doi.org/10.1136/bmjophth-2018-000244 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Original Article
Faes, Livia
Ali, Zaria
Wagner, Siegfried
Patel, Praveen J
Fu, Dun Jack
Bachmann, Lucas M
Schmid, Martin K
Waheed, Nadia
Keane, Pearse A
Balaskas, Konstantinos
Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series
title Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series
title_full Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series
title_fullStr Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series
title_full_unstemmed Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series
title_short Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series
title_sort effect of total anti-vegf treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528762/
https://www.ncbi.nlm.nih.gov/pubmed/31179393
http://dx.doi.org/10.1136/bmjophth-2018-000244
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