Cargando…

dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer

OBJECTIVES: Decreased deoxycytidine kinase (dCK) expression is a reported indicator of gemcitabine efficacy in pancreatic cancer, due to the impact of this kinase on gemcitabine metabolism. The transcription factor NF‐E2 p45‐related factor 2 (NRF2, also called Nfe2l2), a master regulator of redox ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Qiangsheng, Qin, Yi, Xiang, Jinfeng, Liu, Wensheng, Xu, Wenyan, Sun, Qiqing, Ji, Shunrong, Liu, Jiang, Zhang, Zheng, Ni, Quanxing, Xu, Jin, Yu, Xianjun, Zhang, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528851/ https://www.ncbi.nlm.nih.gov/pubmed/29701272 http://dx.doi.org/10.1111/cpr.12456

Ejemplares similares

PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis
por: Qin, Yi, et al.
Publicado: (2019)

ABO Blood Group and the Risk of Pancreatic Neoplasms in Chinese Han Population: A Study at Shanghai Pancreatic Cancer Institute
por: Liu, Mengqi, et al.
Publicado: (2019)

TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer
por: Xiang, Jinfeng, et al.
Publicado: (2018)

MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine
por: Wensheng, Liu, et al.
Publicado: (2019)

Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma
por: Sun, Qiqing, et al.
Publicado: (2019)

FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1
por: Hu, Qiangsheng, et al.
Publicado: (2017)

The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer
por: Sun, Qiqing, et al.
Publicado: (2018)

FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells
por: Ye, Zeng, et al.
Publicado: (2020)

Laparoscopic pancreaticoduodenectomy: are the best times coming?
por: Liu, Mengqi, et al.
Publicado: (2019)

The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death
por: Zhong, Rui, et al.
Publicado: (2016)

Pin1 promotes pancreatic cancer progression and metastasis by activation of NF‐κB‐IL‐18 feedback loop
por: Sun, Qiqing, et al.
Publicado: (2020)

Function and regulation of F-box/WD repeat-containing protein 7
por: Zhang, Zheng, et al.
Publicado: (2020)

Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma
por: Yamamoto, Masahiro, et al.
Publicado: (2021)

Ferroptosis: Final destination for cancer?
por: Ye, Zeng, et al.
Publicado: (2020)

Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis
por: Yao, Wantong, et al.
Publicado: (2014)

dCK Expression and Gene Polymorphism With Gemcitabine Chemosensitivity in Patients With Pancreatic Ductal Adenocarcinoma: A Strobe-Compliant Observational Study
por: Xiong, Junjie, et al.
Publicado: (2016)

Diagnostic Accuracy of a CA125-Based Biomarker Panel in Patients with Pancreatic Cancer: A Systematic Review and Meta-Analysis
por: Meng, Qingcai, et al.
Publicado: (2017)

Improved tumor control with antiangiogenic therapy after treatment with gemcitabine and nab‐paclitaxel in pancreatic cancer
por: Zhang, Zheng, et al.
Publicado: (2021)

Diagnostic and prognostic value of carcinoembryonic antigen in pancreatic cancer: a systematic review and meta-analysis
por: Meng, Qingcai, et al.
Publicado: (2017)

ET-7 Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma
por: Yamamoto, Masahiro, et al.
Publicado: (2021)

Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer
por: Elebro, Jacob, et al.
Publicado: (2016)

Minimally invasive enucleation of pancreatic tumors: The main pancreatic duct is no longer a restricted area
por: Li, Zheng, et al.
Publicado: (2023)

Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer
por: Jin, Kaizhou, et al.
Publicado: (2015)

Complex roles of the stroma in the intrinsic resistance to gemcitabine in pancreatic cancer: where we are and where we are going
por: Liang, Chen, et al.
Publicado: (2017)

Pevonedistat Suppresses Pancreatic Cancer Growth via Inactivation of the Neddylation Pathway
por: Xu, Junfeng, et al.
Publicado: (2022)

Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
por: Yang, Hai, et al.
Publicado: (2022)

KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H (2)S axis and contributes to pancreatic cancer growth : Nrf2/CSE/H (2)S axis decreases ROS in pancreatic cancer
por: Fan, Kun, et al.
Publicado: (2022)

ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer
por: Ji, Shunrong, et al.
Publicado: (2015)

Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK
por: Patel, Girijesh Kumar, et al.
Publicado: (2017)

Value of lymphadenectomy in patients with surgically resected pancreatic neuroendocrine tumors
por: Zhang, Zheng, et al.
Publicado: (2022)

ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cells
por: Chen, Haidi, et al.
Publicado: (2021)

DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer
por: Hu, Shu Fang, et al.
Publicado: (2020)

DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines
por: Zhao, Ya-Hui, et al.
Publicado: (2022)

Inhibition of the PIN1-NRF2/GPX4 axis imparts sensitivity to cisplatin in cervical cancer cells: PIN1/NRF2/GPX4 axis in CC
por: Zhang, Zheng, et al.
Publicado: (2022)

Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity
por: Freiburghaus, Catja, et al.
Publicado: (2018)

Gene expression of hENT1, dCK, CDA, dCMPD and topoisomerase IIα as an indicator of chemotherapy response in AML treated with cytarabine and daunorubicin
por: Kulsoom, Bibi, et al.
Publicado: (2018)

Assistententag des Jungen Forums der DGMKG – DCK 2021
por: Thiem, Daniel
Publicado: (2021)

Targeting AHR Increases Pancreatic Cancer Cell Sensitivity to Gemcitabine through the ELAVL1-DCK Pathway
por: Stukas, Darius, et al.
Publicado: (2023)

Mechanical Regulation of Redox Balance via the Induction of the PIN1/NRF2/ARE Axis in Pancreatic Cancer
por: Liang, Chen, et al.
Publicado: (2023)

Modulation of deoxycytidine kinase (dCK) and glycogen synthase kinase (GSK-3β) by anti-CD20 (rituximab) and 2-chlorodeoxyadenosine (2-CdA) in human lymphoid malignancies
por: Al-Katib, Ayad M, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_mv3v2i5354oi9b3m3jon1hg8q2