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Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation
Cerebellar activity supported by PKC-dependent long-term depression in Purkinje cells (PCs) is involved in the stabilization of self-motion based hippocampal representation, but the existence of cerebellar processes underlying integration of allocentric cues remains unclear. Using mutant-mice lackin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529420/ https://www.ncbi.nlm.nih.gov/pubmed/31113954 http://dx.doi.org/10.1038/s41467-019-09958-5 |
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author | Lefort, Julie Marie Vincent, Jean Tallot, Lucille Jarlier, Frédéric De Zeeuw, Chris Innocentius Rondi-Reig, Laure Rochefort, Christelle |
author_facet | Lefort, Julie Marie Vincent, Jean Tallot, Lucille Jarlier, Frédéric De Zeeuw, Chris Innocentius Rondi-Reig, Laure Rochefort, Christelle |
author_sort | Lefort, Julie Marie |
collection | PubMed |
description | Cerebellar activity supported by PKC-dependent long-term depression in Purkinje cells (PCs) is involved in the stabilization of self-motion based hippocampal representation, but the existence of cerebellar processes underlying integration of allocentric cues remains unclear. Using mutant-mice lacking PP2B in PCs (L7-PP2B mice) we here assess the role of PP2B-dependent PC potentiation in hippocampal representation and spatial navigation. L7-PP2B mice display higher susceptibility to spatial map instability relative to the allocentric cue and impaired allocentric as well as self-motion goal-directed navigation. These results indicate that PP2B-dependent potentiation in PCs contributes to maintain a stable hippocampal representation of a familiar environment in an allocentric reference frame as well as to support optimal trajectory toward a goal during navigation. |
format | Online Article Text |
id | pubmed-6529420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65294202019-05-23 Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation Lefort, Julie Marie Vincent, Jean Tallot, Lucille Jarlier, Frédéric De Zeeuw, Chris Innocentius Rondi-Reig, Laure Rochefort, Christelle Nat Commun Article Cerebellar activity supported by PKC-dependent long-term depression in Purkinje cells (PCs) is involved in the stabilization of self-motion based hippocampal representation, but the existence of cerebellar processes underlying integration of allocentric cues remains unclear. Using mutant-mice lacking PP2B in PCs (L7-PP2B mice) we here assess the role of PP2B-dependent PC potentiation in hippocampal representation and spatial navigation. L7-PP2B mice display higher susceptibility to spatial map instability relative to the allocentric cue and impaired allocentric as well as self-motion goal-directed navigation. These results indicate that PP2B-dependent potentiation in PCs contributes to maintain a stable hippocampal representation of a familiar environment in an allocentric reference frame as well as to support optimal trajectory toward a goal during navigation. Nature Publishing Group UK 2019-05-21 /pmc/articles/PMC6529420/ /pubmed/31113954 http://dx.doi.org/10.1038/s41467-019-09958-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lefort, Julie Marie Vincent, Jean Tallot, Lucille Jarlier, Frédéric De Zeeuw, Chris Innocentius Rondi-Reig, Laure Rochefort, Christelle Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation |
title | Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation |
title_full | Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation |
title_fullStr | Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation |
title_full_unstemmed | Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation |
title_short | Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation |
title_sort | impaired cerebellar purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529420/ https://www.ncbi.nlm.nih.gov/pubmed/31113954 http://dx.doi.org/10.1038/s41467-019-09958-5 |
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