A novel UCHL(3) inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair

Triple-negative breast cancer (TNBC) treatment remains a great challenge for clinical practice and novel therapeutic strategies are urgently needed. UCHL3 is a deubiquitinase that is overexpressed in TNBC and correlates with poor prognosis. UCHL3 deubiquitinates RAD51 thereby promoting the recruitme...

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Detalles Bibliográficos
Autores principales: Song, Zhiwang, Tu, Xinyi, Zhou, Qin, Huang, Jinzhou, Chen, Yuping, Liu, Jiaqi, Lee, SeungBaek, Kim, Wootae, Nowsheen, Somaira, Luo, Kuntian, Yuan, Jian, Lou, Zhenkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529448/
https://www.ncbi.nlm.nih.gov/pubmed/31113933
http://dx.doi.org/10.1038/s41419-019-1628-8

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