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Role of the membrane potential in mitochondrial protein unfolding and import

Newly synthesized mitochondrial precursor proteins have to become unfolded to cross the mitochondrial membranes. This unfolding is achieved primarily by mitochondrial Hsp70 (mtHsp70) for presequence-containing precursor proteins. However, the membrane potential across the inner membrane (ΔΨ) could a...

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Detalles Bibliográficos
Autores principales: Sato, Takehiro K., Kawano, Shin, Endo, Toshiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529458/
https://www.ncbi.nlm.nih.gov/pubmed/31114030
http://dx.doi.org/10.1038/s41598-019-44152-z