Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment

Proapoptotic tumor suppressor WWOX is upregulated in the early stage of cancer initiation, which probably provides limitation to cancer growth and progression. Later, WWOX protein is reduced to enhance cancer cell growth, migration, invasiveness and metastasis. To understand how WWOX works in contro...

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Detalles Bibliográficos
Autores principales: Chou, Pei-Yi, Lai, Feng-Jie, Chen, Yu-An, Sie, Yong-Da, Kuo, Hsiang-Ling, Su, Wan-Pei, Wu, Chia-Yun, Liu, Tsung-Yun, Wen, Kuang-Yu, Hsu, Li-Jin, Sze, Chun-I, Chang, Nan-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529460/
https://www.ncbi.nlm.nih.gov/pubmed/31123603
http://dx.doi.org/10.1038/s41420-019-0176-4

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