Rack1 mediates Src binding to drug transporter P-glycoprotein and modulates its activity through regulating Caveolin-1 phosphorylation in breast cancer cells

The failure of chemotherapy and the emergence of multidrug resistance (MDR) are the major obstacles for effective therapy in locally advanced and metastatic breast cancer. Overexpression of the drug transporter P-glycoprotein (P-gp) in cancer cells is one of the main causes of MDR due to its ability...

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Detalles Bibliográficos
Autores principales: Fan, Yanling, Si, Weiyao, Ji, Wei, Wang, Zhiyong, Gao, Zicong, Tian, Ran, Song, Weijie, Zhang, He, Niu, Ruifang, Zhang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529477/
https://www.ncbi.nlm.nih.gov/pubmed/31113938
http://dx.doi.org/10.1038/s41419-019-1633-y

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