Cargando…

The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca(2+) Channels and Mitochondrial Function in Cardiomyocytes

Numerous epidemiological, clinical, and animal studies showed that cardiac function and manifestation of cardiovascular diseases (CVDs) are different between males and females. The underlying reasons for these sex differences are definitely multifactorial, but major evidence points to a causal role...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahmoodzadeh, Shokoufeh, Dworatzek, Elke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529529/
https://www.ncbi.nlm.nih.gov/pubmed/31156557
http://dx.doi.org/10.3389/fendo.2019.00310
_version_ 1783420410327465984
author Mahmoodzadeh, Shokoufeh
Dworatzek, Elke
author_facet Mahmoodzadeh, Shokoufeh
Dworatzek, Elke
author_sort Mahmoodzadeh, Shokoufeh
collection PubMed
description Numerous epidemiological, clinical, and animal studies showed that cardiac function and manifestation of cardiovascular diseases (CVDs) are different between males and females. The underlying reasons for these sex differences are definitely multifactorial, but major evidence points to a causal role of the sex steroid hormone 17β-estradiol (E2) and its receptors (ER) in the physiology and pathophysiology of the heart. Interestingly, it has been shown that cardiac calcium (Ca(2+)) ion channels and mitochondrial function are regulated in a sex-specific manner. Accurate mitochondrial function and Ca(2+) signaling are of utmost importance for adequate heart function and crucial to maintaining the cardiovascular health. Due to the highly sensitive nature of these processes in the heart, this review article highlights the current knowledge regarding sex dimorphisms in the heart implicating the importance of E2 and ERs in the regulation of cardiac mitochondrial function and Ca(2+) ion channels, thus the contractility. In particular, we provide an overview of in-vitro and in-vivo studies using either E2 deficiency; ER deficiency or selective ER activation, which suggest that E2 and ERs are strongly involved in these processes. In this context, this review also discusses the divergent E2-responses resulting from the activation of different ER subtypes in these processes. Detailed understanding of the E2 and ER-mediated molecular and cellular mechanisms in the heart under physiological and pathological conditions may help to design more specifically targeted drugs for the management of CVDs in men and women.
format Online
Article
Text
id pubmed-6529529
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-65295292019-05-31 The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca(2+) Channels and Mitochondrial Function in Cardiomyocytes Mahmoodzadeh, Shokoufeh Dworatzek, Elke Front Endocrinol (Lausanne) Endocrinology Numerous epidemiological, clinical, and animal studies showed that cardiac function and manifestation of cardiovascular diseases (CVDs) are different between males and females. The underlying reasons for these sex differences are definitely multifactorial, but major evidence points to a causal role of the sex steroid hormone 17β-estradiol (E2) and its receptors (ER) in the physiology and pathophysiology of the heart. Interestingly, it has been shown that cardiac calcium (Ca(2+)) ion channels and mitochondrial function are regulated in a sex-specific manner. Accurate mitochondrial function and Ca(2+) signaling are of utmost importance for adequate heart function and crucial to maintaining the cardiovascular health. Due to the highly sensitive nature of these processes in the heart, this review article highlights the current knowledge regarding sex dimorphisms in the heart implicating the importance of E2 and ERs in the regulation of cardiac mitochondrial function and Ca(2+) ion channels, thus the contractility. In particular, we provide an overview of in-vitro and in-vivo studies using either E2 deficiency; ER deficiency or selective ER activation, which suggest that E2 and ERs are strongly involved in these processes. In this context, this review also discusses the divergent E2-responses resulting from the activation of different ER subtypes in these processes. Detailed understanding of the E2 and ER-mediated molecular and cellular mechanisms in the heart under physiological and pathological conditions may help to design more specifically targeted drugs for the management of CVDs in men and women. Frontiers Media S.A. 2019-05-15 /pmc/articles/PMC6529529/ /pubmed/31156557 http://dx.doi.org/10.3389/fendo.2019.00310 Text en Copyright © 2019 Mahmoodzadeh and Dworatzek. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Mahmoodzadeh, Shokoufeh
Dworatzek, Elke
The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca(2+) Channels and Mitochondrial Function in Cardiomyocytes
title The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca(2+) Channels and Mitochondrial Function in Cardiomyocytes
title_full The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca(2+) Channels and Mitochondrial Function in Cardiomyocytes
title_fullStr The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca(2+) Channels and Mitochondrial Function in Cardiomyocytes
title_full_unstemmed The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca(2+) Channels and Mitochondrial Function in Cardiomyocytes
title_short The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca(2+) Channels and Mitochondrial Function in Cardiomyocytes
title_sort role of 17β-estradiol and estrogen receptors in regulation of ca(2+) channels and mitochondrial function in cardiomyocytes
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529529/
https://www.ncbi.nlm.nih.gov/pubmed/31156557
http://dx.doi.org/10.3389/fendo.2019.00310
work_keys_str_mv AT mahmoodzadehshokoufeh theroleof17bestradiolandestrogenreceptorsinregulationofca2channelsandmitochondrialfunctionincardiomyocytes
AT dworatzekelke theroleof17bestradiolandestrogenreceptorsinregulationofca2channelsandmitochondrialfunctionincardiomyocytes
AT mahmoodzadehshokoufeh roleof17bestradiolandestrogenreceptorsinregulationofca2channelsandmitochondrialfunctionincardiomyocytes
AT dworatzekelke roleof17bestradiolandestrogenreceptorsinregulationofca2channelsandmitochondrialfunctionincardiomyocytes