Inhibiting Bone Morphogenetic Protein 4 Type I Receptor Signaling Promotes Remyelination by Potentiating Oligodendrocyte Differentiation

Blocking inhibitory factors within CNS demyelinating lesions is regarded as a promising strategy to promote remyelination. Bone morphogenetic protein 4 (BMP4) is an inhibitory factor present in demyelinating lesions. Noggin, an endogenous antagonist to BMP, has previously been shown to increase the...

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Detalles Bibliográficos
Autores principales: Govier-Cole, Alistair E., Wood, Rhiannon J., Fletcher, Jessica L., Gonsalvez, David G., Merlo, Daniel, Cate, Holly S., Murray, Simon S., Xiao, Junhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529590/
https://www.ncbi.nlm.nih.gov/pubmed/31028086
http://dx.doi.org/10.1523/ENEURO.0399-18.2019

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