Cargando…

Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study

BACKGROUND: There is an urgent need for biomarkers to better stratify patients with idiopathic pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical presentation. We aimed to investigate whether a specific immune cell type from patients with idiopathic pulmonary f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scott, Madeleine K D, Quinn, Katie, Li, Qin, Carroll, Robert, Warsinske, Hayley, Vallania, Francesco, Chen, Shirley, Carns, Mary A, Aren, Kathleen, Sun, Jiehuan, Koloms, Kimberly, Lee, Jungwha, Baral, Jessika, Kropski, Jonathan, Zhao, Hongyu, Herzog, Erica, Martinez, Fernando J, Moore, Bethany B, Hinchcliff, Monique, Denny, Joshua, Kaminski, Naftali, Herazo-Maya, Jose D, Shah, Nigam H, Khatri, Purvesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529612/ https://www.ncbi.nlm.nih.gov/pubmed/30935881 http://dx.doi.org/10.1016/S2213-2600(18)30508-3

Ejemplares similares

Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures
por: Warsinske, Hayley, et al.
Publicado: (2019)

High-throughput quantitative histology in systemic sclerosis skin disease using computer vision
por: Correia, Chase, et al.
Publicado: (2020)

Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?
por: Lakota, Katja, et al.
Publicado: (2012)

Serum Amyloid A Is a Marker for Pulmonary Involvement in Systemic Sclerosis
por: Lakota, Katja, et al.
Publicado: (2015)

KLRD1-expressing natural killer cells predict influenza susceptibility
por: Bongen, Erika, et al.
Publicado: (2018)

Methods to increase reproducibility in differential gene expression via meta-analysis
por: Sweeney, Timothy E., et al.
Publicado: (2017)

SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts
por: Karampitsakos, Theodoros, et al.
Publicado: (2023)

119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response
por: Warsinske, Hayley, et al.
Publicado: (2018)

Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
por: Warsinske, Hayley C., et al.
Publicado: (2018)

Computational drug repositioning of atorvastatin for ulcerative colitis
por: Bai, Lawrence, et al.
Publicado: (2021)

Interpretation of biological experiments changes with evolution of the Gene Ontology and its annotations
por: Tomczak, Aurelie, et al.
Publicado: (2018)

Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis
por: Warsinske, Hayley C., et al.
Publicado: (2016)

Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases
por: Bansal, Ruchi, et al.
Publicado: (2017)

Accumulation of isolevuglandin-modified protein in normal and fibrotic lung
por: Mont, Stacey, et al.
Publicado: (2016)

Multicohort Analysis Identifies Monocyte Gene Signatures to Accurately Monitor Subset-Specific Changes in Human Diseases
por: Vallania, Francesco, et al.
Publicado: (2021)

Molecular Signatures in Skin Associated with Clinical Improvement During Mycophenolate Treatment in Systemic Sclerosis
por: Hinchcliff, Monique, et al.
Publicado: (2013)

Early life immunity in the era of systems biology: understanding development and disease
por: Schaffert, Steven, et al.
Publicado: (2018)

Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases
por: Vallania, Francesco, et al.
Publicado: (2018)

Data Heterogeneity: The Enzyme to Catalyze Translational Bioinformatics?
por: Cahan, Eli M, et al.
Publicado: (2020)

Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model
por: Warsinske, Hayley C., et al.
Publicado: (2017)

Increasing reproducibility, robustness, and generalizability of biomarker selection from meta-analysis using Bayesian methodology
por: Kalesinskas, Laurynas, et al.
Publicado: (2022)

1539. A Nine-Gene Blood-Based Signature Meets the World Health Organization Target Product Profiles for Diagnosis of Active Tuberculosis and Predicting Progression from Latent to Active Disease
por: Gupta, Sanjana, et al.
Publicado: (2022)

Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges
por: Khatri, Purvesh, et al.
Publicado: (2012)

Gene annotation bias impedes biomedical research
por: Haynes, Winston A., et al.
Publicado: (2018)

Clinical characteristics of hypersensitivity pneumonitis: non-fibrotic and fibrotic subtypes
por: Chen, Xueying, et al.
Publicado: (2023)

Can Blood Gene Expression Predict Which Patients with Multiple Sclerosis Will Respond to Interferon?
por: Kaminski, Naftali, et al.
Publicado: (2005)

Impact of Transcriptomics on Our Understanding of Pulmonary Fibrosis
por: Vukmirovic, Milica, et al.
Publicado: (2018)

Anti-fibrotic effect of adipose-derived stem cells on fibrotic scars
por: Vanderstichele, Sophie, et al.
Publicado: (2022)

Integrative phenotyping framework (iPF): integrative clustering of multiple omics data identifies novel lung disease subphenotypes
por: Kim, SungHwan, et al.
Publicado: (2015)

Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis
por: Vukmirovic, Milica, et al.
Publicado: (2017)

Pro-fibrotic SNPs
por: Maxmen, Amy
Publicado: (2009)

Single-cell profiling reveals immune aberrations in progressive idiopathic pulmonary fibrosis
por: Unterman, Avraham, et al.
Publicado: (2023)

Biomarkers in solid organ transplantation: establishing personalized transplantation medicine
por: Roedder, Silke, et al.
Publicado: (2011)

Anti-fibrotic potential of erythropoietin signaling on bone marrow derived fibrotic cell
por: Iwata, Yasunori, et al.
Publicado: (2021)

Toward Early Detection of Idiopathic Pulmonary Fibrosis
por: Schupp, Jonas Christian, et al.
Publicado: (2019)

When Development of the Alveolar Gas Exchange Unit Fails: Universal Single-Cell Lessons from Rare Monogenic Disorders
por: Schupp, Jonas C., et al.
Publicado: (2023)

A Picture Worth a Thousand Words, Created with One Sentence: Using Artificial Intelligence–created Art to Enhance Medical Education
por: Huston, John C., et al.
Publicado: (2023)

Fibulin-6 regulates pro-fibrotic TGF-β responses in neonatal mouse ventricular cardiac fibroblasts
por: Chowdhury, Arpita, et al.
Publicado: (2017)

Local and Systemic CD4(+) T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis
por: Hawkins, Charlene, et al.
Publicado: (2017)

Cell-centred meta-analysis reveals baseline predictors of anti-TNFα non-response in biopsy and blood of patients with IBD
por: Gaujoux, Renaud, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5iohnb0a7i8eqhtttv3oo98moe