Anti-Niemann Pick C1 Single-Stranded Oligonucleotides with Locked Nucleic Acids Potently Reduce Ebola Virus Infection In Vitro

Ebola virus is the causative agent of Ebola virus disease, a severe, often fatal illness in humans. So far, there are no US Food and Drug Administration (FDA)-approved therapeutics directed against Ebola virus. Here, we selected the host factor Niemann-Pick C1 (NPC1), which has been shown to be esse...

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Detalles Bibliográficos
Autores principales: Sadewasser, Anne, Dietzel, Erik, Michel, Sven, Klüver, Michael, Helfer, Markus, Thelemann, Tamara, Klar, Richard, Eickmann, Markus, Becker, Stephan, Jaschinski, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529764/
https://www.ncbi.nlm.nih.gov/pubmed/31125846
http://dx.doi.org/10.1016/j.omtn.2019.04.018

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