Cargando…
The pedunculopontine region and breathing in Parkinson's disease
OBJECTIVE: Respiratory abnormalities such as upper airway obstruction are common in Parkinson's disease (PD) and are an important cause of mortality and morbidity. We tested the effect of pedunculopontine region (PPNr) stimulation on respiratory maneuvers in human participants with PD, and sepa...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529926/ https://www.ncbi.nlm.nih.gov/pubmed/31139681 http://dx.doi.org/10.1002/acn3.752 |
_version_ | 1783420511188942848 |
---|---|
author | Hyam, Jonathan A. Wang, Shouyan Roy, Holly Moosavi, Shakeeb H. Martin, Sean C. Brittain, John Stuart Coyne, Terry Silburn, Peter Aziz, Tipu Z. Green, Alexander L. |
author_facet | Hyam, Jonathan A. Wang, Shouyan Roy, Holly Moosavi, Shakeeb H. Martin, Sean C. Brittain, John Stuart Coyne, Terry Silburn, Peter Aziz, Tipu Z. Green, Alexander L. |
author_sort | Hyam, Jonathan A. |
collection | PubMed |
description | OBJECTIVE: Respiratory abnormalities such as upper airway obstruction are common in Parkinson's disease (PD) and are an important cause of mortality and morbidity. We tested the effect of pedunculopontine region (PPNr) stimulation on respiratory maneuvers in human participants with PD, and separately recorded PPNr neural activity reflected in the local field potential (LFP) during these maneuvers. METHODS: Nine patients with deep brain stimulation electrodes in PPNr, and seven in globus pallidus interna (GPi) were studied during trials of maximal inspiration followed by forced expiration with stimulation OFF and ON. Local field potentials (LFPs) were recorded in the unstimulated condition. RESULTS: PEFR increased from 6.41 ± 0.63 L/sec in the OFF stimulation state to 7.5 L ± 0.65 L/sec in the ON stimulation state (z = −2.666, df = 8, P = 0.024). Percentage improvement in PEFR was strongly correlated with proximity of the stimulated electrode contact to the mesencephalic locomotor region in the rostral PPN (r = 0.814, n = 9, P = 0.008). Mean PPNr LFP power increased within the alpha band (7–11 Hz) during forced respiratory maneuvers (1.63 ± 0.16 μV(2)/Hz) compared to resting breathing (0.77 ± 0.16 μV(2)/Hz; z = −2.197, df = 6, P = 0.028). No changes in alpha activity or spirometric indices were seen with GPi recording or stimulation. Percentage improvement in PEFR was strongly positively correlated with increase in alpha power (r = 0.653, n = 14 (7 PPNr patients recorded bilaterally), P = 0.0096). INTERPRETATION: PPNr stimulation in PD improves indices of upper airway function. Increased alpha‐band activity is seen within the PPNr during forced respiratory maneuvers. Our findings suggest a link between the PPNr and respiratory performance in PD. |
format | Online Article Text |
id | pubmed-6529926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65299262019-05-28 The pedunculopontine region and breathing in Parkinson's disease Hyam, Jonathan A. Wang, Shouyan Roy, Holly Moosavi, Shakeeb H. Martin, Sean C. Brittain, John Stuart Coyne, Terry Silburn, Peter Aziz, Tipu Z. Green, Alexander L. Ann Clin Transl Neurol Research Articles OBJECTIVE: Respiratory abnormalities such as upper airway obstruction are common in Parkinson's disease (PD) and are an important cause of mortality and morbidity. We tested the effect of pedunculopontine region (PPNr) stimulation on respiratory maneuvers in human participants with PD, and separately recorded PPNr neural activity reflected in the local field potential (LFP) during these maneuvers. METHODS: Nine patients with deep brain stimulation electrodes in PPNr, and seven in globus pallidus interna (GPi) were studied during trials of maximal inspiration followed by forced expiration with stimulation OFF and ON. Local field potentials (LFPs) were recorded in the unstimulated condition. RESULTS: PEFR increased from 6.41 ± 0.63 L/sec in the OFF stimulation state to 7.5 L ± 0.65 L/sec in the ON stimulation state (z = −2.666, df = 8, P = 0.024). Percentage improvement in PEFR was strongly correlated with proximity of the stimulated electrode contact to the mesencephalic locomotor region in the rostral PPN (r = 0.814, n = 9, P = 0.008). Mean PPNr LFP power increased within the alpha band (7–11 Hz) during forced respiratory maneuvers (1.63 ± 0.16 μV(2)/Hz) compared to resting breathing (0.77 ± 0.16 μV(2)/Hz; z = −2.197, df = 6, P = 0.028). No changes in alpha activity or spirometric indices were seen with GPi recording or stimulation. Percentage improvement in PEFR was strongly positively correlated with increase in alpha power (r = 0.653, n = 14 (7 PPNr patients recorded bilaterally), P = 0.0096). INTERPRETATION: PPNr stimulation in PD improves indices of upper airway function. Increased alpha‐band activity is seen within the PPNr during forced respiratory maneuvers. Our findings suggest a link between the PPNr and respiratory performance in PD. John Wiley and Sons Inc. 2019-05-01 /pmc/articles/PMC6529926/ /pubmed/31139681 http://dx.doi.org/10.1002/acn3.752 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Hyam, Jonathan A. Wang, Shouyan Roy, Holly Moosavi, Shakeeb H. Martin, Sean C. Brittain, John Stuart Coyne, Terry Silburn, Peter Aziz, Tipu Z. Green, Alexander L. The pedunculopontine region and breathing in Parkinson's disease |
title | The pedunculopontine region and breathing in Parkinson's disease |
title_full | The pedunculopontine region and breathing in Parkinson's disease |
title_fullStr | The pedunculopontine region and breathing in Parkinson's disease |
title_full_unstemmed | The pedunculopontine region and breathing in Parkinson's disease |
title_short | The pedunculopontine region and breathing in Parkinson's disease |
title_sort | pedunculopontine region and breathing in parkinson's disease |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529926/ https://www.ncbi.nlm.nih.gov/pubmed/31139681 http://dx.doi.org/10.1002/acn3.752 |
work_keys_str_mv | AT hyamjonathana thepedunculopontineregionandbreathinginparkinsonsdisease AT wangshouyan thepedunculopontineregionandbreathinginparkinsonsdisease AT royholly thepedunculopontineregionandbreathinginparkinsonsdisease AT moosavishakeebh thepedunculopontineregionandbreathinginparkinsonsdisease AT martinseanc thepedunculopontineregionandbreathinginparkinsonsdisease AT brittainjohnstuart thepedunculopontineregionandbreathinginparkinsonsdisease AT coyneterry thepedunculopontineregionandbreathinginparkinsonsdisease AT silburnpeter thepedunculopontineregionandbreathinginparkinsonsdisease AT aziztipuz thepedunculopontineregionandbreathinginparkinsonsdisease AT greenalexanderl thepedunculopontineregionandbreathinginparkinsonsdisease AT hyamjonathana pedunculopontineregionandbreathinginparkinsonsdisease AT wangshouyan pedunculopontineregionandbreathinginparkinsonsdisease AT royholly pedunculopontineregionandbreathinginparkinsonsdisease AT moosavishakeebh pedunculopontineregionandbreathinginparkinsonsdisease AT martinseanc pedunculopontineregionandbreathinginparkinsonsdisease AT brittainjohnstuart pedunculopontineregionandbreathinginparkinsonsdisease AT coyneterry pedunculopontineregionandbreathinginparkinsonsdisease AT silburnpeter pedunculopontineregionandbreathinginparkinsonsdisease AT aziztipuz pedunculopontineregionandbreathinginparkinsonsdisease AT greenalexanderl pedunculopontineregionandbreathinginparkinsonsdisease |