Human leukocyte antigen associations in postural tachycardia syndrome

Associations between human leukocyte antigen (HLA) and postural orthostatic tachycardia syndrome (POTS) have not been investigated. We included patients diagnosed with POTS and showing orthostatic heart rate increases ≥ 50 during orthostatic vital sign measurement or experiencing syncope/near‐syncop...

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Detalles Bibliográficos
Autores principales: Shin, Yong‐Won, Moon, Jangsup, Kim, Tae‐Joon, Kim, Do‐Yong, Chang, Hyeyeon, Jun, Jin‐Sun, Lee, Soon‐Tae, Jung, Keun‐Hwa, Park, Kyung‐Il, Jung, Ki‐Young, Kim, Manho, Lee, Sang Kun, Chu, Kon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529927/
https://www.ncbi.nlm.nih.gov/pubmed/31139694
http://dx.doi.org/10.1002/acn3.766
Descripción
Sumario:Associations between human leukocyte antigen (HLA) and postural orthostatic tachycardia syndrome (POTS) have not been investigated. We included patients diagnosed with POTS and showing orthostatic heart rate increases ≥ 50 during orthostatic vital sign measurement or experiencing syncope/near‐syncope while standing (prominent POTS; n = 17). DQB1*06:09 was present in seven (41%) patients, a significantly higher percentage than in healthy Koreans (7%; odds ratio [OR] 8.7, 95% confidence interval [CI] 3.1–24.3, corrected P = 3.2 × 10(−4)) and epilepsy controls (8%; OR 7.9, 95% CI 2.7–23.5, corrected P = 3.2 × 10(−4)). Six (35.3%) carried the A*33:03‐B*58:01‐C*03:02‐DRB1*13:02‐DQB1*06:09 haplotype. The results signify an autoimmune etiology in prominent POTS.

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