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Human leukocyte antigen associations in postural tachycardia syndrome
Associations between human leukocyte antigen (HLA) and postural orthostatic tachycardia syndrome (POTS) have not been investigated. We included patients diagnosed with POTS and showing orthostatic heart rate increases ≥ 50 during orthostatic vital sign measurement or experiencing syncope/near‐syncop...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529927/ https://www.ncbi.nlm.nih.gov/pubmed/31139694 http://dx.doi.org/10.1002/acn3.766 |
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| author | Shin, Yong‐Won Moon, Jangsup Kim, Tae‐Joon Kim, Do‐Yong Chang, Hyeyeon Jun, Jin‐Sun Lee, Soon‐Tae Jung, Keun‐Hwa Park, Kyung‐Il Jung, Ki‐Young Kim, Manho Lee, Sang Kun Chu, Kon |
| author_facet | Shin, Yong‐Won Moon, Jangsup Kim, Tae‐Joon Kim, Do‐Yong Chang, Hyeyeon Jun, Jin‐Sun Lee, Soon‐Tae Jung, Keun‐Hwa Park, Kyung‐Il Jung, Ki‐Young Kim, Manho Lee, Sang Kun Chu, Kon |
| author_sort | Shin, Yong‐Won |
| collection | PubMed |
| description | Associations between human leukocyte antigen (HLA) and postural orthostatic tachycardia syndrome (POTS) have not been investigated. We included patients diagnosed with POTS and showing orthostatic heart rate increases ≥ 50 during orthostatic vital sign measurement or experiencing syncope/near‐syncope while standing (prominent POTS; n = 17). DQB1*06:09 was present in seven (41%) patients, a significantly higher percentage than in healthy Koreans (7%; odds ratio [OR] 8.7, 95% confidence interval [CI] 3.1–24.3, corrected P = 3.2 × 10(−4)) and epilepsy controls (8%; OR 7.9, 95% CI 2.7–23.5, corrected P = 3.2 × 10(−4)). Six (35.3%) carried the A*33:03‐B*58:01‐C*03:02‐DRB1*13:02‐DQB1*06:09 haplotype. The results signify an autoimmune etiology in prominent POTS. |
| format | Online Article Text |
| id | pubmed-6529927 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-65299272019-05-28 Human leukocyte antigen associations in postural tachycardia syndrome Shin, Yong‐Won Moon, Jangsup Kim, Tae‐Joon Kim, Do‐Yong Chang, Hyeyeon Jun, Jin‐Sun Lee, Soon‐Tae Jung, Keun‐Hwa Park, Kyung‐Il Jung, Ki‐Young Kim, Manho Lee, Sang Kun Chu, Kon Ann Clin Transl Neurol Brief Communications Associations between human leukocyte antigen (HLA) and postural orthostatic tachycardia syndrome (POTS) have not been investigated. We included patients diagnosed with POTS and showing orthostatic heart rate increases ≥ 50 during orthostatic vital sign measurement or experiencing syncope/near‐syncope while standing (prominent POTS; n = 17). DQB1*06:09 was present in seven (41%) patients, a significantly higher percentage than in healthy Koreans (7%; odds ratio [OR] 8.7, 95% confidence interval [CI] 3.1–24.3, corrected P = 3.2 × 10(−4)) and epilepsy controls (8%; OR 7.9, 95% CI 2.7–23.5, corrected P = 3.2 × 10(−4)). Six (35.3%) carried the A*33:03‐B*58:01‐C*03:02‐DRB1*13:02‐DQB1*06:09 haplotype. The results signify an autoimmune etiology in prominent POTS. John Wiley and Sons Inc. 2019-04-04 /pmc/articles/PMC6529927/ /pubmed/31139694 http://dx.doi.org/10.1002/acn3.766 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| spellingShingle | Brief Communications Shin, Yong‐Won Moon, Jangsup Kim, Tae‐Joon Kim, Do‐Yong Chang, Hyeyeon Jun, Jin‐Sun Lee, Soon‐Tae Jung, Keun‐Hwa Park, Kyung‐Il Jung, Ki‐Young Kim, Manho Lee, Sang Kun Chu, Kon Human leukocyte antigen associations in postural tachycardia syndrome |
| title | Human leukocyte antigen associations in postural tachycardia syndrome |
| title_full | Human leukocyte antigen associations in postural tachycardia syndrome |
| title_fullStr | Human leukocyte antigen associations in postural tachycardia syndrome |
| title_full_unstemmed | Human leukocyte antigen associations in postural tachycardia syndrome |
| title_short | Human leukocyte antigen associations in postural tachycardia syndrome |
| title_sort | human leukocyte antigen associations in postural tachycardia syndrome |
| topic | Brief Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529927/ https://www.ncbi.nlm.nih.gov/pubmed/31139694 http://dx.doi.org/10.1002/acn3.766 |
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