Clinical significance of soluble adhesion molecules in anti‐NMDAR encephalitis patients

Increasing evidence indicates that immune system dysfunction affects anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis. This study aims to investigate the relationship between adhesion molecules and the pathophysiology in anti‐NMDAR encephalitis. Soluble forms of Intercellular adhesion molecul...

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Autores principales: Ding, Yuewen, Yang, Chengjia, Zhou, Zheyi, Peng, Yu, Chen, Jinyu, Pan, Suyue, Xu, Hong, Cai, Yuping, Ou, Kaiyun, Xie, Wei, Wang, Honghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529932/
https://www.ncbi.nlm.nih.gov/pubmed/31139692
http://dx.doi.org/10.1002/acn3.740
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author Ding, Yuewen
Yang, Chengjia
Zhou, Zheyi
Peng, Yu
Chen, Jinyu
Pan, Suyue
Xu, Hong
Cai, Yuping
Ou, Kaiyun
Xie, Wei
Wang, Honghao
author_facet Ding, Yuewen
Yang, Chengjia
Zhou, Zheyi
Peng, Yu
Chen, Jinyu
Pan, Suyue
Xu, Hong
Cai, Yuping
Ou, Kaiyun
Xie, Wei
Wang, Honghao
author_sort Ding, Yuewen
collection PubMed
description Increasing evidence indicates that immune system dysfunction affects anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis. This study aims to investigate the relationship between adhesion molecules and the pathophysiology in anti‐NMDAR encephalitis. Soluble forms of Intercellular adhesion molecule‐1 (sICAM‐1), vascular adhesion molecule‐1 (sVCAM‐1), and L‐selectin (sL‐selectin), were measured in the CSF and serum of 26 participants with anti‐NMDAR encephalitis, 11 patients with schizophrenia and 22 patients with noninflammatory disorders. CSF levels of sICAM‐1, sVCAM‐1 and sL‐selectin were significantly elevated in the anti‐NMDAR encephalitis group. sVCAM‐1 levels were positively associated with modified Rankin scale score in anti‐NMDAR encephalitis patients at the onset and 3‐month follow‐up.
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spelling pubmed-65299322019-05-28 Clinical significance of soluble adhesion molecules in anti‐NMDAR encephalitis patients Ding, Yuewen Yang, Chengjia Zhou, Zheyi Peng, Yu Chen, Jinyu Pan, Suyue Xu, Hong Cai, Yuping Ou, Kaiyun Xie, Wei Wang, Honghao Ann Clin Transl Neurol Brief Communications Increasing evidence indicates that immune system dysfunction affects anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis. This study aims to investigate the relationship between adhesion molecules and the pathophysiology in anti‐NMDAR encephalitis. Soluble forms of Intercellular adhesion molecule‐1 (sICAM‐1), vascular adhesion molecule‐1 (sVCAM‐1), and L‐selectin (sL‐selectin), were measured in the CSF and serum of 26 participants with anti‐NMDAR encephalitis, 11 patients with schizophrenia and 22 patients with noninflammatory disorders. CSF levels of sICAM‐1, sVCAM‐1 and sL‐selectin were significantly elevated in the anti‐NMDAR encephalitis group. sVCAM‐1 levels were positively associated with modified Rankin scale score in anti‐NMDAR encephalitis patients at the onset and 3‐month follow‐up. John Wiley and Sons Inc. 2019-04-11 /pmc/articles/PMC6529932/ /pubmed/31139692 http://dx.doi.org/10.1002/acn3.740 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Ding, Yuewen
Yang, Chengjia
Zhou, Zheyi
Peng, Yu
Chen, Jinyu
Pan, Suyue
Xu, Hong
Cai, Yuping
Ou, Kaiyun
Xie, Wei
Wang, Honghao
Clinical significance of soluble adhesion molecules in anti‐NMDAR encephalitis patients
title Clinical significance of soluble adhesion molecules in anti‐NMDAR encephalitis patients
title_full Clinical significance of soluble adhesion molecules in anti‐NMDAR encephalitis patients
title_fullStr Clinical significance of soluble adhesion molecules in anti‐NMDAR encephalitis patients
title_full_unstemmed Clinical significance of soluble adhesion molecules in anti‐NMDAR encephalitis patients
title_short Clinical significance of soluble adhesion molecules in anti‐NMDAR encephalitis patients
title_sort clinical significance of soluble adhesion molecules in anti‐nmdar encephalitis patients
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529932/
https://www.ncbi.nlm.nih.gov/pubmed/31139692
http://dx.doi.org/10.1002/acn3.740
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