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Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies

A longitudinal study was performed in three Danish farrow to grower (30 kilos) herds over a 4-month period to investigate the dynamics and clinical impacts of influenza A virus (IAV) infections. In each herd, four batches consisting of four sows each with five ear-tagged piglets were included. Nasal...

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Autores principales: Ryt-Hansen, Pia, Larsen, Inge, Kristensen, Charlotte Sonne, Krog, Jesper Schak, Wacheck, Silke, Larsen, Lars Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530179/
https://www.ncbi.nlm.nih.gov/pubmed/31113477
http://dx.doi.org/10.1186/s13567-019-0655-x
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author Ryt-Hansen, Pia
Larsen, Inge
Kristensen, Charlotte Sonne
Krog, Jesper Schak
Wacheck, Silke
Larsen, Lars Erik
author_facet Ryt-Hansen, Pia
Larsen, Inge
Kristensen, Charlotte Sonne
Krog, Jesper Schak
Wacheck, Silke
Larsen, Lars Erik
author_sort Ryt-Hansen, Pia
collection PubMed
description A longitudinal study was performed in three Danish farrow to grower (30 kilos) herds over a 4-month period to investigate the dynamics and clinical impacts of influenza A virus (IAV) infections. In each herd, four batches consisting of four sows each with five ear-tagged piglets were included. Nasal swabs and/or blood were sampled from the sows and/or the piglets prior to farrowing and at weeks 1, 3, and 5 and at the end of the nursery period. Clinical examinations were performed at each sampling time. The sows and piglets were tested for IAV and IAV antibodies in nasal swabs and blood samples, respectively. The results revealed three enzootically infected herds, where the majority of the pigs were infected during the first 5 weeks after birth. Infected piglets of only 3 days of age were detected in the farrowing unit, where the sows were also shedding virus. In all herds, low to moderate numbers of infected pigs (ranging from 3.6 to 20.7%) were found to be virus positive in nasal swabs at two consecutive sampling times. Furthermore, clinical signs of respiratory disease were associated with IAV detection. The findings of this study documented that IAV can persist in herds and that piglets as young as 3 days can be infected despite the presence of maternally derived antibodies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13567-019-0655-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-65301792019-05-28 Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies Ryt-Hansen, Pia Larsen, Inge Kristensen, Charlotte Sonne Krog, Jesper Schak Wacheck, Silke Larsen, Lars Erik Vet Res Research Article A longitudinal study was performed in three Danish farrow to grower (30 kilos) herds over a 4-month period to investigate the dynamics and clinical impacts of influenza A virus (IAV) infections. In each herd, four batches consisting of four sows each with five ear-tagged piglets were included. Nasal swabs and/or blood were sampled from the sows and/or the piglets prior to farrowing and at weeks 1, 3, and 5 and at the end of the nursery period. Clinical examinations were performed at each sampling time. The sows and piglets were tested for IAV and IAV antibodies in nasal swabs and blood samples, respectively. The results revealed three enzootically infected herds, where the majority of the pigs were infected during the first 5 weeks after birth. Infected piglets of only 3 days of age were detected in the farrowing unit, where the sows were also shedding virus. In all herds, low to moderate numbers of infected pigs (ranging from 3.6 to 20.7%) were found to be virus positive in nasal swabs at two consecutive sampling times. Furthermore, clinical signs of respiratory disease were associated with IAV detection. The findings of this study documented that IAV can persist in herds and that piglets as young as 3 days can be infected despite the presence of maternally derived antibodies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13567-019-0655-x) contains supplementary material, which is available to authorized users. BioMed Central 2019-05-22 2019 /pmc/articles/PMC6530179/ /pubmed/31113477 http://dx.doi.org/10.1186/s13567-019-0655-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ryt-Hansen, Pia
Larsen, Inge
Kristensen, Charlotte Sonne
Krog, Jesper Schak
Wacheck, Silke
Larsen, Lars Erik
Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies
title Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies
title_full Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies
title_fullStr Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies
title_full_unstemmed Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies
title_short Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies
title_sort longitudinal field studies reveal early infection and persistence of influenza a virus in piglets despite the presence of maternally derived antibodies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530179/
https://www.ncbi.nlm.nih.gov/pubmed/31113477
http://dx.doi.org/10.1186/s13567-019-0655-x
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