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Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence

Epigenetic mechanisms have been suggested to play a role in the genetic regulation of pathways related to inflammation. Therefore, we aimed to systematically review studies investigating the association between DNA methylation and histone modifications with circulatory inflammation markers in blood....

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Autores principales: Gonzalez-Jaramillo, Valentina, Portilla-Fernandez, Eliana, Glisic, Marija, Voortman, Trudy, Ghanbari, Mohsen, Bramer, Wichor, Chowdhury, Rajiv, Nijsten, Tamar, Dehghan, Abbas, Franco, Oscar H., Nano, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530203/
https://www.ncbi.nlm.nih.gov/pubmed/31205673
http://dx.doi.org/10.1155/2019/6273680
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author Gonzalez-Jaramillo, Valentina
Portilla-Fernandez, Eliana
Glisic, Marija
Voortman, Trudy
Ghanbari, Mohsen
Bramer, Wichor
Chowdhury, Rajiv
Nijsten, Tamar
Dehghan, Abbas
Franco, Oscar H.
Nano, Jana
author_facet Gonzalez-Jaramillo, Valentina
Portilla-Fernandez, Eliana
Glisic, Marija
Voortman, Trudy
Ghanbari, Mohsen
Bramer, Wichor
Chowdhury, Rajiv
Nijsten, Tamar
Dehghan, Abbas
Franco, Oscar H.
Nano, Jana
author_sort Gonzalez-Jaramillo, Valentina
collection PubMed
description Epigenetic mechanisms have been suggested to play a role in the genetic regulation of pathways related to inflammation. Therefore, we aimed to systematically review studies investigating the association between DNA methylation and histone modifications with circulatory inflammation markers in blood. Five bibliographic databases were screened until 21 November of 2017. We included studies conducted on humans that examined the association between epigenetic marks (DNA methylation and/or histone modifications) and a comprehensive list of inflammatory markers. Of the 3,759 identified references, 24 articles were included, involving, 17,399 individuals. There was suggestive evidence for global hypomethylation but better-quality studies in the future have to confirm this. Epigenome-wide association studies (EWAS) (n=7) reported most of the identified differentially methylated genes to be hypomethylated in inflammatory processes. Candidate genes studies reported 18 differentially methylated genes related to several circulatory inflammation markers. There was no overlap in the methylated sites investigated in candidate gene studies and EWAS, except for TMEM49, which was found to be hypomethylated with higher inflammatory markers in both types of studies. The relation between histone modifications and inflammatory markers was assessed by one study only. This review supports an association between epigenetic marks and inflammation, suggesting hypomethylation of the genome. Important gaps in the quality of studies were reported such as inadequate sample size, lack of adjustment for relevant confounders, and failure to replicate the findings. While most of the studies have been focused on C-reactive protein, further efforts should investigate other inflammatory markers.
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spelling pubmed-65302032019-06-16 Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence Gonzalez-Jaramillo, Valentina Portilla-Fernandez, Eliana Glisic, Marija Voortman, Trudy Ghanbari, Mohsen Bramer, Wichor Chowdhury, Rajiv Nijsten, Tamar Dehghan, Abbas Franco, Oscar H. Nano, Jana Int J Inflam Review Article Epigenetic mechanisms have been suggested to play a role in the genetic regulation of pathways related to inflammation. Therefore, we aimed to systematically review studies investigating the association between DNA methylation and histone modifications with circulatory inflammation markers in blood. Five bibliographic databases were screened until 21 November of 2017. We included studies conducted on humans that examined the association between epigenetic marks (DNA methylation and/or histone modifications) and a comprehensive list of inflammatory markers. Of the 3,759 identified references, 24 articles were included, involving, 17,399 individuals. There was suggestive evidence for global hypomethylation but better-quality studies in the future have to confirm this. Epigenome-wide association studies (EWAS) (n=7) reported most of the identified differentially methylated genes to be hypomethylated in inflammatory processes. Candidate genes studies reported 18 differentially methylated genes related to several circulatory inflammation markers. There was no overlap in the methylated sites investigated in candidate gene studies and EWAS, except for TMEM49, which was found to be hypomethylated with higher inflammatory markers in both types of studies. The relation between histone modifications and inflammatory markers was assessed by one study only. This review supports an association between epigenetic marks and inflammation, suggesting hypomethylation of the genome. Important gaps in the quality of studies were reported such as inadequate sample size, lack of adjustment for relevant confounders, and failure to replicate the findings. While most of the studies have been focused on C-reactive protein, further efforts should investigate other inflammatory markers. Hindawi 2019-05-08 /pmc/articles/PMC6530203/ /pubmed/31205673 http://dx.doi.org/10.1155/2019/6273680 Text en Copyright © 2019 Valentina Gonzalez-Jaramillo et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gonzalez-Jaramillo, Valentina
Portilla-Fernandez, Eliana
Glisic, Marija
Voortman, Trudy
Ghanbari, Mohsen
Bramer, Wichor
Chowdhury, Rajiv
Nijsten, Tamar
Dehghan, Abbas
Franco, Oscar H.
Nano, Jana
Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
title Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
title_full Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
title_fullStr Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
title_full_unstemmed Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
title_short Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
title_sort epigenetics and inflammatory markers: a systematic review of the current evidence
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530203/
https://www.ncbi.nlm.nih.gov/pubmed/31205673
http://dx.doi.org/10.1155/2019/6273680
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