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Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease

Reactive oxygen species (ROS) and autophagy are two highly complex and interrelated components of cell physiopathology, but our understanding of their integration and their contribution to cell homeostasis and disease is still limited. Sestrins (SESNs) belong to a family of highly conserved stress-i...

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Autores principales: Cordani, Marco, Sánchez-Álvarez, Miguel, Strippoli, Raffaele, Bazhin, Alexandr V., Donadelli, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530209/
https://www.ncbi.nlm.nih.gov/pubmed/31205582
http://dx.doi.org/10.1155/2019/1283075
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author Cordani, Marco
Sánchez-Álvarez, Miguel
Strippoli, Raffaele
Bazhin, Alexandr V.
Donadelli, Massimo
author_facet Cordani, Marco
Sánchez-Álvarez, Miguel
Strippoli, Raffaele
Bazhin, Alexandr V.
Donadelli, Massimo
author_sort Cordani, Marco
collection PubMed
description Reactive oxygen species (ROS) and autophagy are two highly complex and interrelated components of cell physiopathology, but our understanding of their integration and their contribution to cell homeostasis and disease is still limited. Sestrins (SESNs) belong to a family of highly conserved stress-inducible proteins that orchestrate antioxidant and autophagy-regulating functions protecting cells from various noxious stimuli, including DNA damage, oxidative stress, hypoxia, and metabolic stress. They are also relevant modulators of metabolism as positive regulators of the key energy sensor AMP-dependent protein kinase (AMPK) and inhibitors of mammalian target of rapamycin complex 1 (mTORC1). Since perturbations in these pathways are central to multiple disorders, SESNs might constitute potential novel therapeutic targets of broad interest. In this review, we discuss the current understanding of regulatory and effector networks of SESNs, highlighting their significance as potential biomarkers and therapeutic targets for different diseases, such as aging-related diseases, metabolic disorders, neurodegenerative diseases, and cancer.
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spelling pubmed-65302092019-06-16 Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease Cordani, Marco Sánchez-Álvarez, Miguel Strippoli, Raffaele Bazhin, Alexandr V. Donadelli, Massimo Oxid Med Cell Longev Review Article Reactive oxygen species (ROS) and autophagy are two highly complex and interrelated components of cell physiopathology, but our understanding of their integration and their contribution to cell homeostasis and disease is still limited. Sestrins (SESNs) belong to a family of highly conserved stress-inducible proteins that orchestrate antioxidant and autophagy-regulating functions protecting cells from various noxious stimuli, including DNA damage, oxidative stress, hypoxia, and metabolic stress. They are also relevant modulators of metabolism as positive regulators of the key energy sensor AMP-dependent protein kinase (AMPK) and inhibitors of mammalian target of rapamycin complex 1 (mTORC1). Since perturbations in these pathways are central to multiple disorders, SESNs might constitute potential novel therapeutic targets of broad interest. In this review, we discuss the current understanding of regulatory and effector networks of SESNs, highlighting their significance as potential biomarkers and therapeutic targets for different diseases, such as aging-related diseases, metabolic disorders, neurodegenerative diseases, and cancer. Hindawi 2019-05-07 /pmc/articles/PMC6530209/ /pubmed/31205582 http://dx.doi.org/10.1155/2019/1283075 Text en Copyright © 2019 Marco Cordani et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cordani, Marco
Sánchez-Álvarez, Miguel
Strippoli, Raffaele
Bazhin, Alexandr V.
Donadelli, Massimo
Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
title Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
title_full Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
title_fullStr Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
title_full_unstemmed Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
title_short Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
title_sort sestrins at the interface of ros control and autophagy regulation in health and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530209/
https://www.ncbi.nlm.nih.gov/pubmed/31205582
http://dx.doi.org/10.1155/2019/1283075
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