Cargando…
The Role of the Microbiota in the Diabetic Peripheral Artery Disease
Vascular complications of diabetes mellitus represent a major public health problem. Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota a...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530226/ https://www.ncbi.nlm.nih.gov/pubmed/31205450 http://dx.doi.org/10.1155/2019/4128682 |
_version_ | 1783420587848237056 |
---|---|
author | Biscetti, Federico Nardella, Elisabetta Cecchini, Andrea Leonardo Landolfi, Raffaele Flex, Andrea |
author_facet | Biscetti, Federico Nardella, Elisabetta Cecchini, Andrea Leonardo Landolfi, Raffaele Flex, Andrea |
author_sort | Biscetti, Federico |
collection | PubMed |
description | Vascular complications of diabetes mellitus represent a major public health problem. Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota and the initiation, promotion, and evolution of atherosclerotic disease, even in the diabetic scenario. There is an urgency to develop the knowledge of modern medicine about the link between gut microbiota and its host's metabolic pathways, and it would be useful to understand and justify the interindividual diversity of clinical disease presentation of diabetic vascular complication even if an optimization of pharmacological treatment has been made or in the case of young patients where hypertension, dyslipidemia, and diabetes are not able to justify a very quick progress of atherosclerotic process. The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the microbiota in this field, from biomarker to possible therapeutic target. |
format | Online Article Text |
id | pubmed-6530226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65302262019-06-16 The Role of the Microbiota in the Diabetic Peripheral Artery Disease Biscetti, Federico Nardella, Elisabetta Cecchini, Andrea Leonardo Landolfi, Raffaele Flex, Andrea Mediators Inflamm Review Article Vascular complications of diabetes mellitus represent a major public health problem. Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota and the initiation, promotion, and evolution of atherosclerotic disease, even in the diabetic scenario. There is an urgency to develop the knowledge of modern medicine about the link between gut microbiota and its host's metabolic pathways, and it would be useful to understand and justify the interindividual diversity of clinical disease presentation of diabetic vascular complication even if an optimization of pharmacological treatment has been made or in the case of young patients where hypertension, dyslipidemia, and diabetes are not able to justify a very quick progress of atherosclerotic process. The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the microbiota in this field, from biomarker to possible therapeutic target. Hindawi 2019-05-08 /pmc/articles/PMC6530226/ /pubmed/31205450 http://dx.doi.org/10.1155/2019/4128682 Text en Copyright © 2019 Federico Biscetti et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Biscetti, Federico Nardella, Elisabetta Cecchini, Andrea Leonardo Landolfi, Raffaele Flex, Andrea The Role of the Microbiota in the Diabetic Peripheral Artery Disease |
title | The Role of the Microbiota in the Diabetic Peripheral Artery Disease |
title_full | The Role of the Microbiota in the Diabetic Peripheral Artery Disease |
title_fullStr | The Role of the Microbiota in the Diabetic Peripheral Artery Disease |
title_full_unstemmed | The Role of the Microbiota in the Diabetic Peripheral Artery Disease |
title_short | The Role of the Microbiota in the Diabetic Peripheral Artery Disease |
title_sort | role of the microbiota in the diabetic peripheral artery disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530226/ https://www.ncbi.nlm.nih.gov/pubmed/31205450 http://dx.doi.org/10.1155/2019/4128682 |
work_keys_str_mv | AT biscettifederico theroleofthemicrobiotainthediabeticperipheralarterydisease AT nardellaelisabetta theroleofthemicrobiotainthediabeticperipheralarterydisease AT cecchiniandrealeonardo theroleofthemicrobiotainthediabeticperipheralarterydisease AT landolfiraffaele theroleofthemicrobiotainthediabeticperipheralarterydisease AT flexandrea theroleofthemicrobiotainthediabeticperipheralarterydisease AT biscettifederico roleofthemicrobiotainthediabeticperipheralarterydisease AT nardellaelisabetta roleofthemicrobiotainthediabeticperipheralarterydisease AT cecchiniandrealeonardo roleofthemicrobiotainthediabeticperipheralarterydisease AT landolfiraffaele roleofthemicrobiotainthediabeticperipheralarterydisease AT flexandrea roleofthemicrobiotainthediabeticperipheralarterydisease |