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Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside

Sepsis is one of the most serious health hazards. Current research suggests that the pathogenesis of sepsis is mediated by both pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Mitochondria are among the most important organelles in cells and determine...

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Detalles Bibliográficos
Autores principales: Li, Sicheng, Hu, Qiongyuan, Huang, Jinjian, Wu, Xiuwen, Ren, Jianan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530230/
https://www.ncbi.nlm.nih.gov/pubmed/31205588
http://dx.doi.org/10.1155/2019/6914849
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author Li, Sicheng
Hu, Qiongyuan
Huang, Jinjian
Wu, Xiuwen
Ren, Jianan
author_facet Li, Sicheng
Hu, Qiongyuan
Huang, Jinjian
Wu, Xiuwen
Ren, Jianan
author_sort Li, Sicheng
collection PubMed
description Sepsis is one of the most serious health hazards. Current research suggests that the pathogenesis of sepsis is mediated by both pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Mitochondria are among the most important organelles in cells and determine their life and death. A variety of mitochondria-derived DAMPs (mtDAMPs) are similar to bacteria because mitochondria are derived from bacteria according to the mitochondrial endosymbiotic theory. Their activated signaling pathways extensively affect organ functions, the immune system, and metabolic functions in sepsis. In this review, we describe the essential roles of mtDAMPs in sepsis and discuss their research prospects and clinical importance.
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spelling pubmed-65302302019-06-16 Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside Li, Sicheng Hu, Qiongyuan Huang, Jinjian Wu, Xiuwen Ren, Jianan Oxid Med Cell Longev Review Article Sepsis is one of the most serious health hazards. Current research suggests that the pathogenesis of sepsis is mediated by both pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Mitochondria are among the most important organelles in cells and determine their life and death. A variety of mitochondria-derived DAMPs (mtDAMPs) are similar to bacteria because mitochondria are derived from bacteria according to the mitochondrial endosymbiotic theory. Their activated signaling pathways extensively affect organ functions, the immune system, and metabolic functions in sepsis. In this review, we describe the essential roles of mtDAMPs in sepsis and discuss their research prospects and clinical importance. Hindawi 2019-05-08 /pmc/articles/PMC6530230/ /pubmed/31205588 http://dx.doi.org/10.1155/2019/6914849 Text en Copyright © 2019 Sicheng Li et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Sicheng
Hu, Qiongyuan
Huang, Jinjian
Wu, Xiuwen
Ren, Jianan
Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside
title Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside
title_full Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside
title_fullStr Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside
title_full_unstemmed Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside
title_short Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside
title_sort mitochondria-derived damage-associated molecular patterns in sepsis: from bench to bedside
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530230/
https://www.ncbi.nlm.nih.gov/pubmed/31205588
http://dx.doi.org/10.1155/2019/6914849
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