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Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease
Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the development of new drugs. In this scenario, Asteraceae...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530400/ https://www.ncbi.nlm.nih.gov/pubmed/31156427 http://dx.doi.org/10.3389/fphar.2019.00477 |
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author | Moraes Neto, Roberval Nascimento Setúbal, Ruth Flávia Barros Higino, Taciana Mirely Maciel Brelaz-de-Castro, Maria Carolina Accioly da Silva, Luís Cláudio Nascimento Aliança, Amanda Silva dos Santos |
author_facet | Moraes Neto, Roberval Nascimento Setúbal, Ruth Flávia Barros Higino, Taciana Mirely Maciel Brelaz-de-Castro, Maria Carolina Accioly da Silva, Luís Cláudio Nascimento Aliança, Amanda Silva dos Santos |
author_sort | Moraes Neto, Roberval Nascimento |
collection | PubMed |
description | Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the development of new drugs. In this scenario, Asteraceae plants (a family widely used in folk medicine worldwide) are emerging as an interesting source for new trypanocidal and leishmanicidal compounds. Herein, we provide a non-exhaustive review about the activity of plant-derived products from Asteraceae with inhibitory action toward Leishmania spp. and T. cruzi. Special attention was given to those studies aiming the isolation (or identification) of the bioactive compounds. Ferulic acid, rosmarinic acid, and ursolic acid (Baccharis uncinella DC.) were efficient to treat experimental leishmaniasis; while deoxymikanolide (Mikania micrantha) and (+)-15-hydroxy-labd-7-en-17-al (Aristeguietia glutinosa Lam.) showed in vivo anti-T. cruzi action. It is also important to highlight that several plant-derived products (compounds, essential oils) from Artemisia plants have shown high inhibitory potential against Leishmania spp., such as artemisinin and its derivatives. In summary, these compounds may help the development of new effective agents against these neglected diseases. |
format | Online Article Text |
id | pubmed-6530400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65304002019-05-31 Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease Moraes Neto, Roberval Nascimento Setúbal, Ruth Flávia Barros Higino, Taciana Mirely Maciel Brelaz-de-Castro, Maria Carolina Accioly da Silva, Luís Cláudio Nascimento Aliança, Amanda Silva dos Santos Front Pharmacol Pharmacology Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the development of new drugs. In this scenario, Asteraceae plants (a family widely used in folk medicine worldwide) are emerging as an interesting source for new trypanocidal and leishmanicidal compounds. Herein, we provide a non-exhaustive review about the activity of plant-derived products from Asteraceae with inhibitory action toward Leishmania spp. and T. cruzi. Special attention was given to those studies aiming the isolation (or identification) of the bioactive compounds. Ferulic acid, rosmarinic acid, and ursolic acid (Baccharis uncinella DC.) were efficient to treat experimental leishmaniasis; while deoxymikanolide (Mikania micrantha) and (+)-15-hydroxy-labd-7-en-17-al (Aristeguietia glutinosa Lam.) showed in vivo anti-T. cruzi action. It is also important to highlight that several plant-derived products (compounds, essential oils) from Artemisia plants have shown high inhibitory potential against Leishmania spp., such as artemisinin and its derivatives. In summary, these compounds may help the development of new effective agents against these neglected diseases. Frontiers Media S.A. 2019-05-08 /pmc/articles/PMC6530400/ /pubmed/31156427 http://dx.doi.org/10.3389/fphar.2019.00477 Text en Copyright © 2019 Moraes Neto, Setúbal, Higino, Brelaz-de-Castro, da Silva and Aliança. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Moraes Neto, Roberval Nascimento Setúbal, Ruth Flávia Barros Higino, Taciana Mirely Maciel Brelaz-de-Castro, Maria Carolina Accioly da Silva, Luís Cláudio Nascimento Aliança, Amanda Silva dos Santos Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease |
title | Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease |
title_full | Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease |
title_fullStr | Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease |
title_full_unstemmed | Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease |
title_short | Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease |
title_sort | asteraceae plants as sources of compounds against leishmaniasis and chagas disease |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530400/ https://www.ncbi.nlm.nih.gov/pubmed/31156427 http://dx.doi.org/10.3389/fphar.2019.00477 |
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