Cargando…

Treatment of patients with relapsed or refractory CD19+ lymphoid disease with T lymphocytes transduced by RV-SFG.CD19.CD28.4-1BBzeta retroviral vector: a unicentre phase I/II clinical trial protocol

INTRODUCTION: Chimeric antigen receptor (CAR) T cells spark hope for patients with CD19+ B cell neoplasia, including relapsed or refractory (r/r) acute lymphoblastic leukaemia (ALL) or r/r non-Hodgkin’s lymphoma (NHL). Published studies have mostly used second-generation CARs with 4-1BB or CD28 as c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schubert, Maria-Luisa, Schmitt, Anita, Sellner, Leopold, Neuber, Brigitte, Kunz, Joachim, Wuchter, Patrick, Kunz, Alexander, Gern, Ulrike, Michels, Birgit, Hofmann, Susanne, Hückelhoven-Krauss, Angela, Kulozik, Andreas, Ho, Anthony D., Müller-Tidow, Carsten, Dreger, Peter, Schmitt, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Haematology (Incl Blood Transfusion)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530404/ https://www.ncbi.nlm.nih.gov/pubmed/31110096 http://dx.doi.org/10.1136/bmjopen-2018-026644

Ejemplares similares

Impact of serum-free media on the expansion and functionality of CD19.CAR T-cells
por: Eberhardt, Franziska, et al.
Publicado: (2023)

Third-generation CD28/4-1BB chimeric antigen receptor T cells for chemotherapy relapsed or refractory acute lymphoblastic leukaemia: a non-randomised, open-label phase I trial protocol
por: Tang, Xiao-Yi, et al.
Publicado: (2016)

Third-generation anti-CD19 chimeric antigen receptor T-cells incorporating a TLR2 domain for relapsed or refractory B-cell lymphoma: a phase I clinical trial protocol (ENABLE)
por: George, Philip, et al.
Publicado: (2020)

Sensitivity and Specificity of CD19.CAR-T Cell Detection by Flow Cytometry and PCR
por: Schanda, Nicola, et al.
Publicado: (2021)

Safety and efficacy of post-haematopoietic cell transplantation maintenance therapy with blinatumomab for relapsed/refractory CD19-positive B-cell acute lymphoblastic leukaemia: protocol for a phase I–II, multicentre, non-blinded, non-controlled trial (JPLSG SCT-ALL-BLIN21)
por: Sakaguchi, Hirotoshi, et al.
Publicado: (2023)

Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy
por: Yang, Mingya, et al.
Publicado: (2021)

Optimized Assessment of qPCR-Based Vector Copy Numbers as a Safety Parameter for GMP-Grade CAR T Cells and Monitoring of Frequency in Patients
por: Kunz, Alexander, et al.
Publicado: (2020)

Shaping of CD56(bri) Natural Killer Cells in Patients With Steroid-Refractory/Resistant Acute Graft-vs.-Host Disease via Extracorporeal Photopheresis
por: Ni, Ming, et al.
Publicado: (2019)

Comparison of single copy gene-based duplex quantitative PCR and digital droplet PCR for monitoring of expansion of CD19-directed CAR T cells in treated patients
por: Schubert, Maria-Luisa, et al.
Publicado: (2022)

Pre-sensitization of Malignant B Cells Through Venetoclax Significantly Improves the Cytotoxic Efficacy of CD19.CAR-T Cells
por: Yang, Mingya, et al.
Publicado: (2020)

Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial
por: Schubert, Maria-Luisa, et al.
Publicado: (2023)

Risk Factors for Alloimmunisation after red blood Cell Transfusions (R-FACT): a case cohort study
por: Zalpuri, Saurabh, et al.
Publicado: (2012)

Patient self-assessment of hospital pain, mood and health-related quality of life in adults with sickle cell disease
por: Anie, Kofi A, et al.
Publicado: (2012)

Assessment of whole body MRI and sestamibi technetium-99m bone marrow scan in prediction of multiple myeloma disease progression and outcome: a prospective comparative study
por: Khalafallah, Alhossain A, et al.
Publicado: (2013)

Stem cell transplantation of matched sibling donors compared with immunosuppressive therapy for acquired severe aplastic anaemia: a Cochrane systematic review
por: Peinemann, Frank, et al.
Publicado: (2014)

Current practice of venous thromboembolism prevention in acute trusts: a qualitative study
por: McFarland, L, et al.
Publicado: (2014)

An audit of anticoagulant management to assess anticoagulant control using decision support software
por: Harper, Paul, et al.
Publicado: (2014)

Randomised controlled trial of weekly chloroquine to re-establish normal erythron iron flux and haemoglobin recovery in postmalarial anaemia
por: Cox, Sharon E, et al.
Publicado: (2013)

Intracranial haemorrhage in thrombocytopenic haematology patients—a nested case–control study: the InCiTe study protocol
por: Estcourt, Lise J, et al.
Publicado: (2014)

HFE gene mutation and oxidative damage biomarkers in patients with myelodysplastic syndromes and its relation to transfusional iron overload: an observational cross-sectional study
por: De Souza, Geane Felix, et al.
Publicado: (2015)

A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial
por: Ypma, Paula F, et al.
Publicado: (2016)

Validation of the multivariable In-hospital Mortality for PulmonAry embolism using Claims daTa (IMPACT) prediction rule within an all-payer inpatient administrative claims database
por: Coleman, Craig I, et al.
Publicado: (2015)

Characteristics of platelet indices, neutrophil-to-lymphocyte ratio and erythrocyte sedimentation rate compared with C reactive protein in patients with cerebral infarction: a retrospective analysis of comparing haematological parameters and C reactive protein
por: Lee, Jong-Han, et al.
Publicado: (2014)

Use of heparins in patients with cancer: individual participant data meta-analysis of randomised trials study protocol
por: Schünemann, Holger J, et al.
Publicado: (2016)

Protocol for updating a systematic review of randomised controlled trials on the prophylactic use of intravenous immunoglobulin for patients undergoing haematopoietic stem cell transplantation
por: Cowan, Juthaporn, et al.
Publicado: (2015)

Clinical effects of blood donor characteristics in transfusion recipients: protocol of a framework to study the blood donor–recipient continuum
por: Chassé, Michaël, et al.
Publicado: (2015)

Is self-monitoring an effective option for people receiving long-term vitamin K antagonist therapy? A systematic review and economic evaluation
por: Sharma, Pawana, et al.
Publicado: (2015)

Mutation screening for thalassaemia in the Jino ethnic minority population of Yunnan Province, Southwest China
por: Wang, Shiyun, et al.
Publicado: (2015)

Health-related quality of life after pulmonary embolism: a cross-sectional study
por: Tavoly, Mazdak, et al.
Publicado: (2016)

Gender disparities in red blood cell transfusion in elective surgery: a post hoc multicentre cohort study
por: Gombotz, Hans, et al.
Publicado: (2016)

Aneurysmal SubArachnoid Hemorrhage—Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol
por: English, Shane W, et al.
Publicado: (2016)

Rationale and design of platelet transfusions in haematopoietic stem cell transplantation: the PATH pilot study
por: Tay, Jason, et al.
Publicado: (2016)

Antithrombotic stewardship: a multidisciplinary team approach towards improving antithrombotic therapy outcomes during and after hospitalisation: a study protocol
por: Dreijer, Albert R, et al.
Publicado: (2016)

Is it feasible to conduct a randomised controlled trial of pretransplant exercise (prehabilitation) for patients with multiple myeloma awaiting autologous haematopoietic stem cell transplantation? Protocol for the PREeMPT study
por: Keen, Carol, et al.
Publicado: (2018)

Defining a set of standardised outcome measures for newly diagnosed patients with multiple myeloma using the Delphi consensus method: the IMPORTA project
por: Blade, Joan, et al.
Publicado: (2018)

Dabigatran persistence and adherence in New Zealand: a nationwide retrospective observational study
por: Harper, Paul, et al.
Publicado: (2018)

Effects of vaccines in patients with sickle cell disease: a systematic review protocol
por: Wiyeh, Alison Beriliy, et al.
Publicado: (2018)

Views and attitudes towards blood donation: a qualitative investigation of Indian non-donors living in England
por: Joshi, Dhaara, et al.
Publicado: (2017)

Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery
por: Warner, Matthew A, et al.
Publicado: (2017)

Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana
por: Anie, Kofi A, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_elvrm6qfb9hfff0prpk5bslf7g