Localization of ligands within human carbonic anhydrase II using (19)F pseudocontact shift analysis

Unraveling the native structure of protein–ligand complexes in solution enables rational drug design. We report here the use of (19)F pseudocontact shift (PCS) NMR as a method to determine fluorine positions of high affinity ligands bound within the drug target human carbonic anhydrase II with high...

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Detalles Bibliográficos
Autores principales: Zimmermann, Kaspar, Joss, Daniel, Müntener, Thomas, Nogueira, Elisa S., Schäfer, Marc, Knörr, Livia, Monnard, Fabien W., Häussinger, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530540/
https://www.ncbi.nlm.nih.gov/pubmed/31183057
http://dx.doi.org/10.1039/c8sc05683h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530540/
https://www.ncbi.nlm.nih.gov/pubmed/31183057
http://dx.doi.org/10.1039/c8sc05683h

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