Integration of PEG 400 into a self-nanoemulsifying drug delivery system improves drug loading capacity and nasal mucosa permeability and prolongs the survival of rats with malignant brain tumors

Introduction: Kolliphor(®) EL (K-EL) is among the most useful surfactants in the preparation of emulsions. However, it is associated with low hydrophobic drug loading in the resulting emulsified formulation. Methods: In this study, a formulation for intranasal administration of butylidenephthalide (...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Shuan, Chiu, Yu-Han, Li, Yuan-Sheng, Lin, En-Yi, Hsieh, Dean-Kuo, Lee, Chia-Hung, Huang, Mao-Hsuan, Chuang, Hong-Meng, Lin, Shinn-Zong, Harn, Horng-Jyh, Chiou, Tzyy-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530554/
https://www.ncbi.nlm.nih.gov/pubmed/31190814
http://dx.doi.org/10.2147/IJN.S193617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530554/
https://www.ncbi.nlm.nih.gov/pubmed/31190814
http://dx.doi.org/10.2147/IJN.S193617

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