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Integration of PEG 400 into a self-nanoemulsifying drug delivery system improves drug loading capacity and nasal mucosa permeability and prolongs the survival of rats with malignant brain tumors
Introduction: Kolliphor(®) EL (K-EL) is among the most useful surfactants in the preparation of emulsions. However, it is associated with low hydrophobic drug loading in the resulting emulsified formulation. Methods: In this study, a formulation for intranasal administration of butylidenephthalide (...
Autores principales: | Chen, Yu-Shuan, Chiu, Yu-Han, Li, Yuan-Sheng, Lin, En-Yi, Hsieh, Dean-Kuo, Lee, Chia-Hung, Huang, Mao-Hsuan, Chuang, Hong-Meng, Lin, Shinn-Zong, Harn, Horng-Jyh, Chiou, Tzyy-Wen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530554/ https://www.ncbi.nlm.nih.gov/pubmed/31190814 http://dx.doi.org/10.2147/IJN.S193617 |
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