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MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment

It is important to confirm the dose distribution and its biophysiological response in patients subjected to carbon-ion radiotherapy (CIRT) by using medical imaging methods. In this study, the correlation between the signal intensity changes of muscles observed in magnetic resonance imaging (MRI) aft...

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Autores principales: Kawahara, Masahiro, Kawamura, Hidemasa, Kubota, Yoshiki, Katoh, Hiroyuki, Kubo, Nobuteru, Shimada, Hirofumi, Torikai, Kota, Torikoshi, Masami, Kanai, Tatsuaki, Nakano, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530618/
https://www.ncbi.nlm.nih.gov/pubmed/30668869
http://dx.doi.org/10.1093/jrr/rry111
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author Kawahara, Masahiro
Kawamura, Hidemasa
Kubota, Yoshiki
Katoh, Hiroyuki
Kubo, Nobuteru
Shimada, Hirofumi
Torikai, Kota
Torikoshi, Masami
Kanai, Tatsuaki
Nakano, Takashi
author_facet Kawahara, Masahiro
Kawamura, Hidemasa
Kubota, Yoshiki
Katoh, Hiroyuki
Kubo, Nobuteru
Shimada, Hirofumi
Torikai, Kota
Torikoshi, Masami
Kanai, Tatsuaki
Nakano, Takashi
author_sort Kawahara, Masahiro
collection PubMed
description It is important to confirm the dose distribution and its biophysiological response in patients subjected to carbon-ion radiotherapy (CIRT) by using medical imaging methods. In this study, the correlation between the signal intensity changes of muscles observed in magnetic resonance imaging (MRI) after CIRT and planned dose distribution was evaluated. Seven patients were arbitrarily selected from among localized prostate cancer patients on whom CIRT was performed in our facilities in 2010. All subjects received the same dose of CIRT, namely, 57.6 Gy relative biological effectiveness (RBE) in 16 fractions. The following two types of images were acquired for each subject: planning computed tomography (CT) images overlaying the dose distribution of CIRT and MRI T2-weighted images (T2WI) taken 1 year after CIRT. The fusion image of the planning CT and MRI images was registered by using a treatment-planning system, and the CIRT dose distribution was compared with changes observed in the MRI of the obturator internus muscles located near the prostate. The signal changes in the axial image passing through the isocenter of the planning target volume were digitized, and a scatter diagram was created showing the relationship between the radiation dose and digitized signal changes. A strong correlation between the radiation dose and the MRI signal intensity changes was observed, and a quadratic function was found to have the best fit. However, estimating the dose distribution from the normalized MRI signal intensity is difficult at this point, owing to the wide variation. Therefore, further investigation is required.
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spelling pubmed-65306182019-05-28 MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment Kawahara, Masahiro Kawamura, Hidemasa Kubota, Yoshiki Katoh, Hiroyuki Kubo, Nobuteru Shimada, Hirofumi Torikai, Kota Torikoshi, Masami Kanai, Tatsuaki Nakano, Takashi J Radiat Res Regular Paper It is important to confirm the dose distribution and its biophysiological response in patients subjected to carbon-ion radiotherapy (CIRT) by using medical imaging methods. In this study, the correlation between the signal intensity changes of muscles observed in magnetic resonance imaging (MRI) after CIRT and planned dose distribution was evaluated. Seven patients were arbitrarily selected from among localized prostate cancer patients on whom CIRT was performed in our facilities in 2010. All subjects received the same dose of CIRT, namely, 57.6 Gy relative biological effectiveness (RBE) in 16 fractions. The following two types of images were acquired for each subject: planning computed tomography (CT) images overlaying the dose distribution of CIRT and MRI T2-weighted images (T2WI) taken 1 year after CIRT. The fusion image of the planning CT and MRI images was registered by using a treatment-planning system, and the CIRT dose distribution was compared with changes observed in the MRI of the obturator internus muscles located near the prostate. The signal changes in the axial image passing through the isocenter of the planning target volume were digitized, and a scatter diagram was created showing the relationship between the radiation dose and digitized signal changes. A strong correlation between the radiation dose and the MRI signal intensity changes was observed, and a quadratic function was found to have the best fit. However, estimating the dose distribution from the normalized MRI signal intensity is difficult at this point, owing to the wide variation. Therefore, further investigation is required. Oxford University Press 2019-05 2019-01-22 /pmc/articles/PMC6530618/ /pubmed/30668869 http://dx.doi.org/10.1093/jrr/rry111 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial reuse, please contact journals.permissions@oup.com
spellingShingle Regular Paper
Kawahara, Masahiro
Kawamura, Hidemasa
Kubota, Yoshiki
Katoh, Hiroyuki
Kubo, Nobuteru
Shimada, Hirofumi
Torikai, Kota
Torikoshi, Masami
Kanai, Tatsuaki
Nakano, Takashi
MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment
title MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment
title_full MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment
title_fullStr MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment
title_full_unstemmed MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment
title_short MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment
title_sort mri response of obturator internus muscle to carbon-ion dose in prostate cancer treatment
topic Regular Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530618/
https://www.ncbi.nlm.nih.gov/pubmed/30668869
http://dx.doi.org/10.1093/jrr/rry111
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