Cargando…

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in malaria parasites is poorly understood. We have investigated the role of cAMP in asexual blood stage development of Plasmodium falciparum through conditional disruption of adenylyl cyclase beta (ACβ) and its down...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Avnish, Perrin, Abigail J., Flynn, Helen R., Bisson, Claudine, Withers-Martinez, Chrislaine, Treeck, Moritz, Flueck, Christian, Nicastro, Giuseppe, Martin, Stephen R., Ramos, Andres, Gilberger, Tim W., Snijders, Ambrosius P., Blackman, Michael J., Baker, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530879/ https://www.ncbi.nlm.nih.gov/pubmed/31075098 http://dx.doi.org/10.1371/journal.pbio.3000264

Ejemplares similares

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion
por: Flueck, Christian, et al.
Publicado: (2019)

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1
por: Lidumniece, Elina, et al.
Publicado: (2021)

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite
por: O'Donnell, Rebecca A., et al.
Publicado: (2006)

A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1
por: Tarr, Sarah J., et al.
Publicado: (2020)

An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery
por: Collins, Christine R., et al.
Publicado: (2009)

Cyclic nucleotide signalling in malaria parasites
por: Baker, David A., et al.
Publicado: (2017)

Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony
por: Perrin, Abigail J., et al.
Publicado: (2021)

Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs
por: Das, Sujaan, et al.
Publicado: (2015)

Ca(2+) signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG
por: Balestra, Aurélia C., et al.
Publicado: (2021)

Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function
por: Koussis, Konstantinos, et al.
Publicado: (2020)

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite
por: Ramaprasad, Abhinay, et al.
Publicado: (2022)

Time-Lapse Imaging of Red Blood Cell Invasion by the Rodent Malaria Parasite Plasmodium yoelii
por: Yahata, Kazuhide, et al.
Publicado: (2012)

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress
por: Collins, Christine R., et al.
Publicado: (2013)

A malaria parasite phospholipase facilitates efficient asexual blood stage egress
por: Ramaprasad, Abhinay, et al.
Publicado: (2023)

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite
por: Leykauf, Kerstin, et al.
Publicado: (2010)

A multifunctional serine protease primes the malaria parasite for red blood cell invasion
por: Koussis, Konstantinos, et al.
Publicado: (2009)

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor
por: Tan, Michele S Y, et al.
Publicado: (2021)

Proteolytic Activation of the Essential Parasitophorous Vacuole Cysteine Protease SERA6 Accompanies Malaria Parasite Egress from Its Host Erythrocyte
por: Ruecker, Andrea, et al.
Publicado: (2012)

Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress
por: Nofal, Stephanie D., et al.
Publicado: (2021)

Essentiality of Plasmodium falciparum plasmepsin V
por: Boonyalai, Nonlawat, et al.
Publicado: (2018)

Correction: Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies
por: Olivieri, Anna, et al.
Publicado: (2012)

Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies
por: Olivieri, Anna, et al.
Publicado: (2011)

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin
por: Withers-Martinez, Chrislaine, et al.
Publicado: (2014)

Corrigendum: The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin
por: Withers-Martinez, Chrislaine, et al.
Publicado: (2014)

Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches()
por: Green, Jeffrey, et al.
Publicado: (2014)

The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion
por: Collins, Christine R, et al.
Publicado: (2020)

Molecular Determinants of Binding to the Plasmodium Subtilisin-like Protease 1
por: Fulle, Simone, et al.
Publicado: (2013)

Ultrastructural localization of cyclic GMP and cyclic AMP in rat striatum
Publicado: (1981)

Identification of a Plasmodium falciparum Phospholipid Transfer Protein
por: van Ooij, Christiaan, et al.
Publicado: (2013)

Uncovering the Cyclic AMP Signaling Pathway of the Protozoan Parasite Entamoeba histolytica and Understanding Its Role in Phagocytosis
por: Agarwal, Shalini, et al.
Publicado: (2020)

Cyclic AMP Accumulation in Migraine Induction
por: Chelse, Ana B., et al.
Publicado: (2015)

Role of cyclic AMP in the eye with glaucoma
por: Shim, Myoung Sup, et al.
Publicado: (2017)

Cyclic AMP binding proteins in human breast cancer.
por: Miller, W. R., et al.
Publicado: (1985)

Cyclic AMP binding proteins and prognosis in breast cancer.
por: Miller, W. R., et al.
Publicado: (1990)

Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases
por: Conti, Marco, et al.
Publicado: (2014)

The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress
por: Perrin, Abigail J., et al.
Publicado: (2018)

Cyclic AMP dynamics in the pancreatic β-cell
por: Tengholm, Anders
Publicado: (2012)

Copper Regulates Cyclic AMP-Dependent Lipolysis
por: Krishnamoorthy, Lakshmi, et al.
Publicado: (2016)

Regulation of IP(3) receptors by cyclic AMP
por: Taylor, Colin W.
Publicado: (2017)

Targeting Cyclic AMP Signalling in Hepatocellular Carcinoma
por: Massimi, Mara, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5vis6npja5je5h15gltumaos00