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Targeted delivery using membrane vesicles in prokaryotes
Membrane vesicles (MVs) are lumen-containing spheres of lipid bilayers secreted by all prokaryotes into the extracellular milieu. They have multifunctional roles in stress response, virulence transfer, biofilm formation, and microbial interactions. Remarkably, MVs contain various components, includi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society of Japan (BSJ)
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530884/ https://www.ncbi.nlm.nih.gov/pubmed/31131182 http://dx.doi.org/10.2142/biophysico.16.0_114 |
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author | Tashiro, Yosuke Takaki, Kotaro Futamata, Hiroyuki |
author_facet | Tashiro, Yosuke Takaki, Kotaro Futamata, Hiroyuki |
author_sort | Tashiro, Yosuke |
collection | PubMed |
description | Membrane vesicles (MVs) are lumen-containing spheres of lipid bilayers secreted by all prokaryotes into the extracellular milieu. They have multifunctional roles in stress response, virulence transfer, biofilm formation, and microbial interactions. Remarkably, MVs contain various components, including lytic enzymes, genetic materials, and hydrophobic signals, at high concentrations and transfer them effectively to the target microbial cells. Therefore, MVs act as carriers for bactericidal effects, horizontal gene transfer, and quorum sensing. Although the purpose of secreted MVs remains unclear, recent reports have provided evidence that MVs selectively interact with microbial cells in order to transfer their content to the target species. Herein, we review microbial interactions using MVs and discuss MV-mediated selective delivery of their content to target microbial cells. |
format | Online Article Text |
id | pubmed-6530884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Biophysical Society of Japan (BSJ) |
record_format | MEDLINE/PubMed |
spelling | pubmed-65308842019-05-24 Targeted delivery using membrane vesicles in prokaryotes Tashiro, Yosuke Takaki, Kotaro Futamata, Hiroyuki Biophys Physicobiol Review Article Membrane vesicles (MVs) are lumen-containing spheres of lipid bilayers secreted by all prokaryotes into the extracellular milieu. They have multifunctional roles in stress response, virulence transfer, biofilm formation, and microbial interactions. Remarkably, MVs contain various components, including lytic enzymes, genetic materials, and hydrophobic signals, at high concentrations and transfer them effectively to the target microbial cells. Therefore, MVs act as carriers for bactericidal effects, horizontal gene transfer, and quorum sensing. Although the purpose of secreted MVs remains unclear, recent reports have provided evidence that MVs selectively interact with microbial cells in order to transfer their content to the target species. Herein, we review microbial interactions using MVs and discuss MV-mediated selective delivery of their content to target microbial cells. The Biophysical Society of Japan (BSJ) 2019-04-19 /pmc/articles/PMC6530884/ /pubmed/31131182 http://dx.doi.org/10.2142/biophysico.16.0_114 Text en 2019 © The Biophysical Society of Japan This article is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-sa/4.0/. |
spellingShingle | Review Article Tashiro, Yosuke Takaki, Kotaro Futamata, Hiroyuki Targeted delivery using membrane vesicles in prokaryotes |
title | Targeted delivery using membrane vesicles in prokaryotes |
title_full | Targeted delivery using membrane vesicles in prokaryotes |
title_fullStr | Targeted delivery using membrane vesicles in prokaryotes |
title_full_unstemmed | Targeted delivery using membrane vesicles in prokaryotes |
title_short | Targeted delivery using membrane vesicles in prokaryotes |
title_sort | targeted delivery using membrane vesicles in prokaryotes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530884/ https://www.ncbi.nlm.nih.gov/pubmed/31131182 http://dx.doi.org/10.2142/biophysico.16.0_114 |
work_keys_str_mv | AT tashiroyosuke targeteddeliveryusingmembranevesiclesinprokaryotes AT takakikotaro targeteddeliveryusingmembranevesiclesinprokaryotes AT futamatahiroyuki targeteddeliveryusingmembranevesiclesinprokaryotes |